| Cat.No.: | PE-0158 |
| Product Name: | Recombinant Human Sirtuin 3, GST-tagged |
| Product Overview: | Full-length recombinant human SIRT3 was expressed in E. coli cells using an N-terminal GST tag. |
| Description: | SIRT3 is a member of the class I of the Sirtuin family that is characterized by a Sirtuin core domain. Sirtuin are grouped into four classes and are homologs to the Sir2 protein. SIRT3 is known to regulate the epigenetic gene silencing and suppresses recombination of rDNA. SIRT3 may function as an intracellular regulatory protein with mono-ADP-ribosyltransferase activity that is essential for its silencing function. |
| Applications: | Western Blot |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 66 kDa |
| Purity: | > 75 % |
| Species: | Human |
| Formulation: | Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1mM PMSF, 25 % glycerol. |
| Tag: | GST |
| Expression System: | E. coli |
| Protein Length: | Full-length |
| Concentrations: | 0.2 ug/ul |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | SIRT3 sirtuin 3 [ Homo sapiens ] |
| Gene ID NCBI: | 23410 |
| Official Symbol: | SIRT3 |
| Synonyms: | SIRT3; sirtuin 3; SIR2L3; NAD-dependent deacetylase sirtuin-3, mitochondrial; sir2-like 3; sirtuin type 3; OTTHUMP00000147616; OTTHUMP00000230525; OTTHUMP00000230526; OTTHUMP00000230527; OTTHUMP00000230528; SIR2-like protein 3; silent mating type information regulation 2, S.cerevisiae, homolog 3; mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase; EC 3.5.1.-; sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae); sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 3 |
| mRNA Refseq: | NM_001017524 |
| Protein Refseq: | NP_001017524 |
| MIM: | 604481 |
| UniProt ID: | Q9NTG7 |
| Chromosome Location: | 11p15.5 |
| Function: | NAD binding; NAD+ ADP-ribosyltransferase activity; hydrolase activity; hydrolase activity; metal ion binding; protein binding; zinc ion binding |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0016 | Recombinant Human SIRT1 Lysate | Inquiry |
| EL-0017 | Recombinant Human SIRT2 293 Cell Lysate | Inquiry |
| EL-0018 | Recombinant Human SIRT3 293 Cell Lysate | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0017 | Fluorogenic Sirtuin 5 Substrate | Inquiry |
| SP-0018 | Fluorogenic Sirtuin 6 Substrate | Inquiry |
| Related Gene / Proteins | |||
| Siah2 | SIK1 | SIMC1 | SIN3A |
| SIN3B | SIP1 | Sir2p | SIRT |
| SIRT1 | SIRT2 | SIRT3 | SIRT4 |
| SIRT5 | sirt6 | SIRT7 | SIX3 |
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