| Cat.No.: | PE-0201 |
| Product Name: | Recombinant Human SIRT7, His-tagged |
| Product Overview: | Full length (2-400aa) recombinant Human SIRT7 expressed in E.coli N-terminal was fused to his-tagged SIRT7. MW = 49.3 kDa. |
| Description: | The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins, which have been designated SIRT1-SIRT7. Recently, SIRT7 has been shown to activate transcription of RNA polymerase I and deacetylate p53. SIRT7 prevents progressive functional deterioration of the heart, and is suggested to play an important role in regulation of stress responses and cell death in the heart. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | ≥85%. |
| Species: | Human |
| Formulation: | 50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride, 5 mM DTT, and 20% glycerol. |
| Tag: | His |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | SIRT7 sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) [ Homo sapiens ] |
| Gene ID NCBI: | 51547 |
| Synonyms: | SIRT7; sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae); SIR2L7; MGC126840; MGC126842; NAD-dependent deacetylase sirtuin-7; sirtuin type 7; SIR2-like protein 7; sir2-related protein type 7; silent mating type information regulation 2, S.cerevisiae, homolog 7; EC 3.5.1.-; sirtuin 7 |
| mRNA Refseq: | NM_016538 |
| Protein Refseq: | NP_057622 |
| MIM: | 606212 |
| UniProt ID: | Q9NRC8 |
| Chromosome Location: | 17q25 |
| Function: | NAD binding; hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; metal ion binding; protein binding; zinc ion binding |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0016 | Recombinant Human SIRT1 Lysate | Inquiry |
| EL-0017 | Recombinant Human SIRT2 293 Cell Lysate | Inquiry |
| EL-0018 | Recombinant Human SIRT3 293 Cell Lysate | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0017 | Fluorogenic Sirtuin 5 Substrate | Inquiry |
| SP-0018 | Fluorogenic Sirtuin 6 Substrate | Inquiry |
| Related Gene / Proteins | |||
| Siah2 | SIK1 | SIMC1 | SIN3A |
| SIN3B | SIP1 | Sir2p | SIRT |
| SIRT1 | SIRT2 | SIRT3 | SIRT4 |
| SIRT5 | sirt6 | SIRT7 | SIX3 |
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