| Cat.No.: | PE-0347 |
| Product Name: | Recombinant Human BRD7, GST-tagged |
| Product Overview: | Recombinant Human BRD7 (a.a.129-252) fussed with GST tag at N-terminal was expressed in E. coli. |
| Description: | The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. Acetylated lysine residues are recognized by a small protein domain known as a bromodomain. These domains function in linking protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as "readers" of histone acetylation marks regulating the transcription of target promoters. BRD7 is a subunit of the polybromo-associated BRG1-associated factor (PBAF)-specific component of the switch/sucrose non-fermentable chromatin-remodeling complex. It has a tumor suppressor role by acting as a cofactor for p53 and regulating breast cancer tumorigenicity. Cells lacking BRD7 have reduced breast cancer type 1-dependent estrogen receptor α expression. Down-regulation of BRD7 has been demonstrated in nasopharyngeal carcinoma cell lines and in colorectal cancer. BRD7 is also involved in transcriptional gene silencing through binding to protein arginine methyltransferase 5 and polycomb repressive complex 2. This protein product contains the bromodomain region of BRD7. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 42.2 kDa |
| Purity: | >40% |
| Species: | Human |
| Formulation: | 50 mM Tris, pH 8.0, containing 150 mM sodium chloride and 20% glycerol |
| Tag: | GST |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | BRD7 bromodomain containing 7 [ Homo sapiens ] |
| Gene ID NCBI: | 29117 |
| Synonyms: | BP75; NAG4; CELTIX1; bromodomain-containing protein 7; 75 kDa bromodomain protein; protein CELTIX-1 |
| mRNA Refseq: | NM_001173984 |
| Protein Refseq: | NP_001167455 |
| Chromosome Location: | 16q12 |
| Function: | histone binding; lysine-acetylated histone binding; p53 binding |
| Product Types | ||
| ◆ Synthetic Peptides | ||
| SP-0001 | Bromodomain Non-Acetylated Ligand 4 | Inquiry |
| SP-0002 | Bromodomain Non-Acetylated Ligand 3 | Inquiry |
| SP-0003 | Bromodomain Non-Acetylated Ligand 1 | Inquiry |
| SP-0004 | Bromodomain Ligand 3 | Inquiry |
| SP-0006 | Bromodomain Ligand 4 | Inquiry |
| Related Gene / Proteins | |||
| BRCA1 | BRCA2 | BRCC3 | BRD |
| brd1 | brd2 | brd3 | brd4 |
| BRD7 | BRD8 | brd9 | brdt |
| BRL | BRM | BRMS1 | BRPF1 |
| BRPF2 | brpf3 | BRWD1 | BRWD3 |
USA
Enter your email here to subscribe.
Follow us on
Easy access to products and services you need from our library via powerful searching tools
