| Cat.No.: | PE-0376 |
| Product Name: | Recombinant Human BRPF3, GST-tagged |
| Product Overview: | Recombinant Human BRPF3 bromodomain (576-701 aa) fused to a GST tag at the N-terminus |
| Description: | The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. Bromodomain and PHD finger containing 3 (BRPF3) is a component of the MOZ/MORF histone acetyltransferase (HAT) complex. The addition of BRPF proteins to MOZ/MORF increases its HAT activity.3 Consequently, BRPF3 is likely to play a role in regulation of transcriptional activation by MOZ/MORF. This product contains the first bromodomain of BRPF3. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 41.2 kDa (576-701 aa + NT GST Tag) |
| Purity: | ≥95% |
| Species: | Human |
| Formulation: | Liquid. 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol. |
| Tag: | GST |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | BRPF3 bromodomain and PHD finger containing, 3 [ Homo sapiens ] |
| Gene ID NCBI: | 27154 |
| Synonyms: | BRPF3; bromodomain and PHD finger containing, 3; bromodomain and PHD finger-containing protein 3; KIAA1286; |
| mRNA Refseq: | NM_015695 |
| Protein Refseq: | NP_056510 |
| UniProt ID: | Q9ULD4 |
| Chromosome Location: | 6p21.31 |
| Function: | metal ion binding; protein binding; zinc ion binding; |
| Product Types | ||
| ◆ Synthetic Peptides | ||
| SP-0001 | Bromodomain Non-Acetylated Ligand 4 | Inquiry |
| SP-0002 | Bromodomain Non-Acetylated Ligand 3 | Inquiry |
| SP-0003 | Bromodomain Non-Acetylated Ligand 1 | Inquiry |
| SP-0004 | Bromodomain Ligand 3 | Inquiry |
| SP-0006 | Bromodomain Ligand 4 | Inquiry |
| Related Gene / Proteins | |||
| BRCA1 | BRCA2 | BRCC3 | BRD |
| brd1 | brd2 | brd3 | brd4 |
| BRD7 | BRD8 | brd9 | brdt |
| BRL | BRM | BRMS1 | BRPF1 |
| BRPF2 | brpf3 | BRWD1 | BRWD3 |
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