| Cat.No.: | PE-0380 |
| Product Name: | Recombinant Mouse CREB Binding Protein, His-tagged |
| Product Overview: | Recombinant Mouse Crebbp produced in SF21 cells. Fused to a His-tag. |
| Description: | First isolated as a nuclear protein that binds to cAMP-response element-binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | ≥95% (SDS-PAGE). |
| Species: | Mouse |
| Formulation: | Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50-100mM imidazole and 10% glycerol. |
| Tag: | His |
| Activity: | ~50-100ng are required for standard HAT assay. |
| Expression System: | Sf21 Insect Cells |
| Concentrations: | 0.5mg/ml. |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | Crebbp CREB binding protein [ Mus musculus ] |
| Gene ID NCBI: | 12914 |
| Synonyms: | Crebbp; CREB binding protein; CBP; RSTS; KAT3A; AW558298; CBP/p300; p300/CBP; EC 2.3.1.48; CREB - binding protein |
| mRNA Refseq: | NM_001025432 |
| Protein Refseq: | NP_001020603 |
| UniProt ID: | P45481.2 |
| Chromosome Location: | 16 A1 |
| Function: | DNA binding; SMAD binding; acetyltransferase activity; histone acetyltransferase activity; metal ion binding; peroxisome proliferator activated receptor binding; signal transducer activity; transcription coactivator activity; transcription coactivator activity; transcription factor activity; transferase activity; zinc ion binding |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0055 | Human CREBBP Knockout Cell Line 1bp insertion | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0094 | C646 | Inquiry |
| BSM-0124 | EML-425 | Inquiry |
| BSM-0150 | I-CBP112 (Hydrochloride) | Inquiry |
| ◆ Research Kits | ||
| EKIT-0122 | CBP bromodomain TR-FRET Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| CREB | CREB3 | crebbp | CRISP1 |
| CRISP3 | CRP | ||
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