| Cat.No.: | PE-0501 |
| Product Name: | Recombinant Mouse Mapk8, GST-tagged, Active |
| Product Overview: | Recombinant full-length mouse JNK1 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag. MW = 71 kDa. |
| Description: | JNK1 is a member of the MAP kinase group that is activated by dual phosphorylation at thr and tyr residues during exposure to stress such as UV irradiation. JNK1 binds to the c-Jun transactivation domain and phosphorylates it on Ser-63 and Ser-73. JNK1 has been shown to play an important role in disease processes. Activation of JNK1 results in defects in myotube viability and integrity leading to dystrophic myofiber destruction. JNK1 activity is also abnormally elevated in obesity and removal of JNK1 results in decreased adiposity and significantly improved insulin sensitivity. |
| Applications: | Kinase Assay, Western Blot. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Species: | Mouse |
| Tag: | GST |
| Expression System: | Sf9 Insect Cells |
| Protein Length: | Full-length. |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | Mapk8 mitogen-activated protein kinase 8 [ Mus musculus ] |
| Gene ID NCBI: | 26419 |
| Synonyms: | Mapk8; mitogen-activated protein kinase 8; JNK; JNK1; Prkm8; SAPK1; AI849689; c-Jun N-terminal kinase; OTTMUSP00000019790; JNK1 beta1 protein kinase; mitogen activated protein kinase 8; protein kinase mitogen-activated 8; EC 2.7.11.24 |
| mRNA Refseq: | NM_016700 |
| Protein Refseq: | NP_057909 |
| Chromosome Location: | 14 B |
| Function: | ATP binding; JUN kinase activity; MAP kinase activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0025 | Human MAGI1 Knockout Cell Line | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0058 | Recombinant Human MAPK8 293 Cell Lysate | Inquiry |
| EL-0059 | Recombinant Human MAPK8 293 Cell Lysate | Inquiry |
| EL-0074 | Recombinant Human MAGEA2 293 Cell Lysate | Inquiry |
| EL-0096 | Recombinant Human MACROD2 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| MACROD2 | MAF | MAFF | MAGEA2 |
| MAGI1 | MAGOH | MAK16 | MALT1 |
| MAPK8 | MASH1 | MASP1 | Mat2A |
| MATR3 | MAX | MAZ | |
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