| Cat.No.: | PE-0506 |
| Product Name: | Recombinant Human Mitogen-Activated Protein Kinase 8, GST-tagged |
| Product Overview: | Recombinant Human JNK1-β1/MAPK8 (K55M) (a.a.2-383) with N-terminal GST tag was expressed in E. coli . MW = 70 kDa. |
| Description: | JNK1 is a member of the MAP kinase group that is activated by dual phosphorylation at thr and tyr residues during exposure to stress such as UV irradiation. JNK1 binds to the c-Jun transactivation domain and phosphorylates it on Ser-63 and Ser-73. JNK1 has been shown to play an important role in disease processes. Activation of JNK1 results in defects in myotube viability and integrity leading to dystrophic myofiber destruction. JNK1 activity is also abnormally elevated in obesity and removal of JNK1 results in decreased adiposity and significantly improved insulin sensitivity. |
| Applications: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | ≥85%. |
| Species: | Human |
| Formulation: | 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 20% glycerol, and 3 mM DTT. |
| Tag: | GST |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | MAPK8 mitogen-activated protein kinase 8 [ Homo sapiens ] |
| Gene ID NCBI: | 5599 |
| Synonyms: | mitogen-activated protein kinase 8; JNK; JNK1; PRKM8; SAPK1; JNK1A2; JNK21B1/2; MAPK8; JNK-46; MAPK 8; MAP kinase 8; protein kinase JNK1; JUN N-terminal kinase; JNK1 beta protein kinase; JNK1 alpha protein kinase; c-Jun N-terminal kinase 1; stress-activated protein kinase 1; stress-activated protein kinase JNK1; mitogen-activated protein kinase 8 isoform JNK1 beta2; mitogen-activated protein kinase 8 isoform JNK1 alpha1; Stress-activated protein kinase JNK1; EC 2.7.11.24; OTTHUMP00000019552 |
| mRNA Refseq: | NM_002750.2 |
| Protein Refseq: | NP_002741.1 |
| MIM: | 601158 |
| UniProt ID: | P45983 |
| Chromosome Location: | 10q11.22 |
| Function: | ATP binding; JUN kinase activity; MAP kinase activity; kinase activity; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0025 | Human MAGI1 Knockout Cell Line | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0058 | Recombinant Human MAPK8 293 Cell Lysate | Inquiry |
| EL-0059 | Recombinant Human MAPK8 293 Cell Lysate | Inquiry |
| EL-0074 | Recombinant Human MAGEA2 293 Cell Lysate | Inquiry |
| EL-0096 | Recombinant Human MACROD2 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| MACROD2 | MAF | MAFF | MAGEA2 |
| MAGI1 | MAGOH | MAK16 | MALT1 |
| MAPK8 | MASH1 | MASP1 | Mat2A |
| MATR3 | MAX | MAZ | |
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