| Cat.No.: | PE-0507 |
| Product Name: | Recombinant Mouse Mitogen-Activated Protein Kinase 8, GST-Tagged |
| Product Overview: | Recombinant full-length mouse JNK1 was expressed in E. coli cells using an N-terminal GST tag. |
| Description: | Mapk8 is a member of the MAP kinase group that is activated by dual phosphorylation at thr and tyr residues during exposure to stress such as UV irradiation. Mapk8 binds to the c-Jun transactivation domain and phosphorylates it on Ser-63 and Ser-73. Mapk8 has been shown to play an important role in disease processes. Activation of Mapk8 results in defects in myotube viability and integrity leading to dystrophic myofiber destruction. Mapk8 activity is also abnormally elevated in obesity and removal of Mapk8 results in decreased adiposity and significantly improved insulin sensitivity. |
| Applications: | Kinase Assay, Western Blot |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 70 kDa |
| Purity: | > 90 % |
| Species: | Human |
| Formulation: | Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 0.25 mM DTT, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol. |
| Tag: | GST |
| Expression System: | E. coli |
| Protein Length: | Full-length |
| Concentrations: | 0.1 ug/ul |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | Mapk8 mitogen-activated protein kinase 8 [ Mus musculus ] |
| Gene ID NCBI: | 26419 |
| Synonyms: | Mapk8; mitogen-activated protein kinase 8; JNK; JNK1; Prkm8; SAPK1; AI849689; c-Jun N-terminal kinase; JNK1 beta1 protein kinase; mitogen activated protein kinase 8; protein kinase mitogen-activated 8; EC 2.7.11.24; OTTMUSP00000019790 |
| mRNA Refseq: | NM_016700 |
| Protein Refseq: | NP_057909 |
| UniProt ID: | Q91Y86 |
| Chromosome Location: | 14 B |
| Function: | ATP binding; JUN kinase activity; MAP kinase activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0025 | Human MAGI1 Knockout Cell Line | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0058 | Recombinant Human MAPK8 293 Cell Lysate | Inquiry |
| EL-0059 | Recombinant Human MAPK8 293 Cell Lysate | Inquiry |
| EL-0074 | Recombinant Human MAGEA2 293 Cell Lysate | Inquiry |
| EL-0096 | Recombinant Human MACROD2 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| MACROD2 | MAF | MAFF | MAGEA2 |
| MAGI1 | MAGOH | MAK16 | MALT1 |
| MAPK8 | MASH1 | MASP1 | Mat2A |
| MATR3 | MAX | MAZ | |
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