| Cat.No.: | PE-0508 |
| Product Name: | Recombinant Human MAPK8 |
| Product Overview: | Recombinant fragment, corresponding to amino acids 2-383 of Human JNK1, with a N terminal proprietary tag. Mw: 71 kDa. |
| Description: | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Sequence Similarities: | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.Contains 1 protein kinase domain. |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | MAPK8 mitogen-activated protein kinase 8 [ Homo sapiens ] |
| Gene ID NCBI: | 5599 |
| Official Symbol: | MAPK8 |
| Synonyms: | MAPK8; mitogen-activated protein kinase 8; PRKM8; JNK; JNK1; JUN N terminal kinase; SAPK1; |
| mRNA Refseq: | NM_002750 |
| Protein Refseq: | NP_002741 |
| MIM: | 601158 |
| UniProt ID: | P45983 |
| Chromosome Location: | 10q11 |
| Function: | ATP binding; JUN kinase activity; MAP kinase activity; histone deacetylase binding; histone deacetylase regulator activity; |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0025 | Human MAGI1 Knockout Cell Line | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0058 | Recombinant Human MAPK8 293 Cell Lysate | Inquiry |
| EL-0059 | Recombinant Human MAPK8 293 Cell Lysate | Inquiry |
| EL-0074 | Recombinant Human MAGEA2 293 Cell Lysate | Inquiry |
| EL-0096 | Recombinant Human MACROD2 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| MACROD2 | MAF | MAFF | MAGEA2 |
| MAGI1 | MAGOH | MAK16 | MALT1 |
| MAPK8 | MASH1 | MASP1 | Mat2A |
| MATR3 | MAX | MAZ | |
USA
Enter your email here to subscribe.
Follow us on
Easy access to products and services you need from our library via powerful searching tools
