Cat.No.: | PE-0509 |
Product Name: | Recombinant Human MAPK8, GST-tagged |
Product Overview: | Recombinant Human MAPK8 was expressed as gst-tagged fusion protein by E.Coli and puri?ed by GSH-sepharose. |
Description: | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. |
Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
Species: | Human |
Tag: | GST |
Expression System: | E. coli |
Protein Length: | 1-427aa |
Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Gene Name: | MAPK8 mitogen-activated protein kinase 8 [ Homo sapiens (human) ] |
Gene ID NCBI: | 5599 |
Synonyms: | MAPK8; JNK; JNK1; PRKM8; SAPK1; JNK-46; JNK1A2; SAPK1c; JNK21B1/2; mitogen-activated protein kinase 8; mitogen-activated protein kinase 8; MAP kinase 8; JUN N-terminal kinase; c-Jun N-terminal kinase 1; stress-activated protein kinase 1; stress-activated protein kinase 1c; mitogen-activated protein kinase 8 isoform JNK1 beta2; mitogen-activated protein kinase 8 isoform JNK1 alpha1; NP_001265476.1; EC 2.7.11.24; NP_001265477.1; NP_002741.1; NP_620634.1; NP_620637.1 |
mRNA Refseq: | NM_001278547 |
Protein Refseq: | NP_001265476 |
MIM: | 601158 |
Chromosome Location: | 10q11.22 |
Function: | ATP binding; JUN kinase activity; histone deacetylase binding |
Product Types | ||
◆ Cell Lines | ||
CL-0025 | Human MAGI1 Knockout Cell Line | Inquiry |
◆ Extracts & Lysates | ||
EL-0058 | Recombinant Human MAPK8 293 Cell Lysate | Inquiry |
EL-0059 | Recombinant Human MAPK8 293 Cell Lysate | Inquiry |
EL-0074 | Recombinant Human MAGEA2 293 Cell Lysate | Inquiry |
EL-0096 | Recombinant Human MACROD2 293 Cell Lysate | Inquiry |
Related Gene / Proteins | |||
MACROD2 | MAF | MAFF | MAGEA2 |
MAGI1 | MAGOH | MAK16 | MALT1 |
MAPK8 | MASH1 | MASP1 | Mat2A |
MATR3 | MAX | MAZ |
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