| Cat.No.: | PE-0598 |
| Product Name: | Recombinant Human Nuclear Receptor Corepressor 2, GST-tagged |
| Product Overview: | Recombinant humanNCOR2 DAD domain (amino acids 395-489) with N-terminal GST tag. |
| Description: | NCOR2 are transcriptional corepresoors thatplay an essential role in the regulation of development and metabolism. Theinteraction of HDAC3 with the deacetylase activation domain (DAD) of NCOR2 isrequired for activation of the otherwise inert deacetylase. |
| Applications: | Enzymekinetics; Screening inhibitors; Selectivity profiling. The optimal antibodyconcentration should be determined for each specific application. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 39 kDa |
| Species: | Human |
| Formulation: | Liquid in 50 mMTris-HCl, pH 8.0 + 138 mM NaCl +20 mM glutathione +10% glycerol. |
| Tag: | GST |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | NCOR2 nuclear receptorcorepressor 2 [ Homo sapiens ] |
| Gene ID NCBI: | 9612 |
| Synonyms: | NCOR2; nuclearreceptor corepressor 2; SMRT; TRAC; CTG26;SMRTE; TRAC1; N-CoR2; TNRC14; TRAC-1; SMAP270; FLJ25011; SMRTE-tau; nuclearreceptor corepressor 2; OTTHUMP00000197398; OTTHUMP00000197399;OTTHUMP00000197400; OTTHUMP00000197402; CTG repeat protein 26; T3receptor-associating factor; thyroid-, retinoic-acid-receptor-associatedcorepressor; silencing mediator for retinoid and thyroid hormone receptors |
| mRNA Refseq: | NM_006312 |
| Protein Refseq: | NP_006303 |
| MIM: | 600848 |
| Chromosome Location: | 12q24 |
| Function: | Notch binding; chromatin binding; histonedeacetylase binding; protein N-terminus binding; protein binding; sequence-specificDNA binding; transcription corepressor activity |
| Product Types | ||
| ◆ Research Kits | ||
| EKIT-0046 | HDAC3/NCOR1 fluorometric drug discovery Kit | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0046 | Recombinant Human NCOR1, GST-tagged | Inquiry |
| ◆ Antibodies | ||
| EAb-0065 | NCOA1 Polyclonal Antibody | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0143 | Recombinant Human NCOA1 293 Cell Lysate | Inquiry |
| EL-0144 | Recombinant Human NCOA2 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| NCAPD3 | NCAPH2 | NCOA1 | NCOA2 |
| NCOA3 | NCoA4 | NCOR1 | ncor2 |
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