Cat.No.: | PE-0631 |
Product Name: | Recombinant Human NCOR1, FLAG-tagged |
Product Overview: | Recombinant full length human Nuclear Receptor Corepressor NCoR with DDDDK tag expressed in Baculovirus system; amino acids 1-2440, 270kDa. |
Description: | This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20. |
Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
Appearance: | Liquid |
Purity: | >95% by SDS-PAGE |
Species: | Human |
Tag: | Flag |
Sequence Similarities: | Belongs to the N-CoR nuclear receptor corepressors family.Contains 2 SANT domains. |
Activity: | NCOR1-28430TH has been tested for deacetylation activity in vitro in the presence of HDAC3. |
Expression System: | Baculovirus |
Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Gene Name: | NCOR1 nuclear receptor corepressor 1 [ Homo sapiens ] |
Gene ID NCBI: | 9611 |
Official Symbol: | NCOR1 |
Synonyms: | NCOR1; nuclear receptor corepressor 1; nuclear receptor co repressor 1; hCIT529I10; hN CoR; KIAA1047; MGC104216; N CoR; thyroid hormone and retinoic acid receptor associated corepressor 1; TRAC1; |
mRNA Refseq: | NM_001190438 |
Protein Refseq: | NP_001177367 |
MIM: | 600849 |
UniProt ID: | O75376 |
Chromosome Location: | 17p11.2 |
Function: | histone deacetylase binding; histone deacetylase regulator activity; protein binding; retinoid X receptor binding; sequence-specific DNA binding; |
Product Types | ||
◆ Research Kits | ||
EKIT-0046 | HDAC3/NCOR1 fluorometric drug discovery Kit | Inquiry |
◆ Proteins & Enzymes | ||
PE-0046 | Recombinant Human NCOR1, GST-tagged | Inquiry |
◆ Antibodies | ||
EAb-0065 | NCOA1 Polyclonal Antibody | Inquiry |
◆ Extracts & Lysates | ||
EL-0143 | Recombinant Human NCOA1 293 Cell Lysate | Inquiry |
EL-0144 | Recombinant Human NCOA2 293 Cell Lysate | Inquiry |
Related Gene / Proteins | |||
NCAPD3 | NCAPH2 | NCOA1 | NCOA2 |
NCOA3 | NCoA4 | NCOR1 | ncor2 |
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