| Cat.No.: | PE-0634 |
| Product Name: | Recombinant Human NCOR1 protein, His & T7-tagged |
| Product Overview: | Recombinant Human NCOR1 aa. (Met1~Val284 (Accession # O75376)) fused with N-terminal His & T7 tag was produced in E. coli cells. |
| Description: | This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20. |
| Applications: | SDS-PAGE; WB; ELISA; IP. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Freeze-dried powder |
| Molecular Weight: | 40kDa as determined by SDS-PAGE reducing conditions. |
| Purity: | >90% |
| Species: | Human |
| Tag: | His & T7 |
| Endotoxin: | <1.0EU per 1ug (determined by the LAL method) |
| Reconstitution: | Reconstitute in sterile ddH2O. |
| Expression System: | E. coli |
| Isoelectric Point: | The isoelectric point is 6.7. |
| Protein Length: | Met1~Val284 (Accession # O75376) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | NCOR1 nuclear receptor corepressor 1 [ Homo sapiens (human) ] |
| Gene ID NCBI: | 9611 |
| Official Symbol: | NCOR1 |
| Synonyms: | NCOR1; nuclear receptor corepressor 1; N-CoR; TRAC1; N-CoR1; hN-CoR; PPP1R109; nuclear receptor corepressor 1; protein phosphatase 1, regulatory subunit 109; thyroid hormone- and retinoic acid receptor-associated corepressor 1 |
| mRNA Refseq: | NM_001190438.1 |
| Protein Refseq: | NP_001177367.1 |
| UniProt ID: | O75376 |
| Product Types | ||
| ◆ Research Kits | ||
| EKIT-0046 | HDAC3/NCOR1 fluorometric drug discovery Kit | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0046 | Recombinant Human NCOR1, GST-tagged | Inquiry |
| ◆ Antibodies | ||
| EAb-0065 | NCOA1 Polyclonal Antibody | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0143 | Recombinant Human NCOA1 293 Cell Lysate | Inquiry |
| EL-0144 | Recombinant Human NCOA2 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| NCAPD3 | NCAPH2 | NCOA1 | NCOA2 |
| NCOA3 | NCoA4 | NCOR1 | ncor2 |
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