| Cat.No.: | PE-0637 |
| Product Name: | Recombinant Human K(lysine) Acetyltransferase 2B, GST-tagged |
| Product Overview: | Recombinant human PCAF (431-end) was expressed in E. coli cells using a N-terminal GST tag. MW = 69 kDa. |
| Description: | PCAF is a protein that shows homology to the yeast GCN5 and associates with p300/CBP. PCAF has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. PCAF encodes a predicted 832-amino acid protein that showed by RNA blotting to be expressed in all tissues, most strongly in heart and skeletal muscle. PCAF has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. PCAF is required for MyoD activity and muscle differentiation. PCAF directly acetylated MyoD which then displays an increased affinity for its DNA target. |
| Applications: | Kinase Assay, Western Blot. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Species: | Human |
| Tag: | GST |
| Expression System: | E. coli |
| Protein Length: | 431-end. |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | KAT2B K(lysine) acetyltransferase 2B [ Homo sapiens ] |
| Gene ID NCBI: | 8850 |
| Synonyms: | KAT2B; K(lysine) acetyltransferase 2B; P; CAF; PCAF; P/CAF; CREBBP-associated factor; p300/CBP-associated factor; Histone acetyltransferase KAT2B; EC 2.3.1.48; Lysine acetyltransferase 2B; Histone acetylase PCAF; P300/CBP-associated factor; P/CAF; GCN5; GCN5L |
| mRNA Refseq: | NM_003884 |
| Protein Refseq: | NP_003875 |
| MIM: | 602303 |
| UniProt ID: | Q92831 |
| Chromosome Location: | 3p24 |
| Function: | histone acetyltransferase activity; histone deacetylase binding; transcription coactivator activity; transferase activity |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0073 | Anacardic Acid | Inquiry |
| ◆ Antibodies | ||
| EAb-0073 | KAT8 Polyclonal Antibody | Inquiry |
| ◆ Cell Lines | ||
| CL-0083 | Human KAT2A Knockout Cell Line 1bp insertion | Inquiry |
| CL-0085 | Human KAT2B Knockout Cell Line 31bp deletion | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0159 | Recombinant Human MYST2 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| Kaiso | KANSL2 | KAP1 | KAT13A |
| KAT13D | KAT2A | KAT2B | KAT4 |
| KAT5 | KAT6A | KAT6B | KAT7 |
| KAT8 | KAT9 | ||
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