| Cat.No.: | PE-0887 |
| Product Name: | Recombinant Human KAT2A, His-tagged |
| Product Overview: | Human GCN5 is fused to a His-tag. |
| Description: | GCN5 functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. It has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. It regulates Tats transactivating activity and may help inducing chromatin remodeling of proviral genes. GCN5 is a component of the Ada Two-A containing (ATAC) complex, a complex with histone acetyltransferase activity on histones H3 and H4. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | ≥95% (SDS-PAGE) |
| Species: | Human |
| Formulation: | Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50mM imidazole and 10% glycerol. |
| Tag: | His |
| Activity: | ~200-300ng are required for standard HAT assay. |
| Expression System: | Sf21 Insect Cells |
| Concentrations: | Lot dependent (0.2-0.5mg/ml) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | KAT2A K(lysine) acetyltransferase 2A [ Homo sapiens ] |
| Gene ID NCBI: | 2648 |
| Synonyms: | KAT2A; K(lysine) acetyltransferase 2A; GCN5 general control of amino acid synthesis 5 like 2 (yeast) , GCN5L2; histone acetyltransferase KAT2A; GCN5; PCAF b; STAF97; hsGCN5; lysine acetyltransferase 2A; histone acetyltransferase GCN5; general control of amino acid synthesis protein 5-like 2; General control of amino acid synthesis, yeast, homolog-like 2; GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2; hGCN5; GCN5L2; PCAF-b; MGC102791; |
| mRNA Refseq: | NM_021078 |
| Protein Refseq: | NP_066564 |
| MIM: | 602301 |
| UniProt ID: | Q92830 |
| Chromosome Location: | 17q12-q21 |
| Function: | H3 histone acetyltransferase activity; chromatin binding; histone acetyltransferase activity; contributes_to histone acetyltransferase activity; histone acetyltransferase activity (H4-K12 specific); histone deacetylase binding; protein binding; transcription coactivator activity; transferase activity; |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0073 | Anacardic Acid | Inquiry |
| ◆ Antibodies | ||
| EAb-0073 | KAT8 Polyclonal Antibody | Inquiry |
| ◆ Cell Lines | ||
| CL-0083 | Human KAT2A Knockout Cell Line 1bp insertion | Inquiry |
| CL-0085 | Human KAT2B Knockout Cell Line 31bp deletion | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0159 | Recombinant Human MYST2 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| Kaiso | KANSL2 | KAP1 | KAT13A |
| KAT13D | KAT2A | KAT2B | KAT4 |
| KAT5 | KAT6A | KAT6B | KAT7 |
| KAT8 | KAT9 | ||
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