| Cat.No.: | PE-0931 |
| Product Name: | Recombinant Human TRDMT1, GST-tagged |
| Product Overview: | Recombinant Human DNMT2, (a-a 2-292), with N-terminal GST tag expressed in baculovirus . MW=71 kDa. |
| Description: | CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a protein with similarity to DNA methyltransferases, but this protein does not display methyltransferase activity. The protein strongly binds DNA, suggesting that it may mark specific sequences in the genome. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Applications: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | >80%. |
| Species: | Human |
| Formulation: | 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 10% glycerol. |
| Tag: | GST |
| Expression System: | Baculovirus |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | TRDMT1 tRNA aspartic acid methyltransferase 1 [ Homo sapiens ] |
| Gene ID NCBI: | 1787 |
| Synonyms: | TRDMT1; tRNA aspartic acid methyltransferase 1; DMNT2; DNMT2; PuMet; RNMT1; M.HsaIIP; DNA methyltransferase-2; DNA MTase homolog HsaIIP; DNA methyltransferase homolog HsaIIP; DNA (cytosine-5-)-methyltransferase 2; EC 2.1.1.29 |
| mRNA Refseq: | NM_004412 |
| Protein Refseq: | NP_004403 |
| MIM: | 602478 |
| UniProt ID: | O14717 |
| Chromosome Location: | 10p15.5 |
| Function: | DNA (cytosine-5-)-methyltransferase activity; RNA binding; methyltransferase activity; tRNA (cytosine-5-)-methyltransferase activity transferase activity; DNA binding |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
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| ◆ Extracts & Lysates | ||
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| Related Gene / Proteins | |||
| TRA2A | TRAF4 | TRAF5 | TRAF6 |
| TRAK2 | TRBP | TRDMT1 | TREX1 |
| TRF2 | TRIM11 | TRIM13 | TRIM16 |
| TRIM17 | TRIM2 | TRIM21 | trim24 |
| TRIM26 | TRIM28 | TRIM3 | TRIM33 More > |
| TRIM34 | TRIM35 | TRIM36 | TRIM37 |
| TRIM38 | TRIM39 | TRIM4 | TRIM5 |
| TRIM55 | TRIM6 | TRIM63 | TRIM66 |
| TRIM68 | TRIM8 | TRIM9 | TRIML1 |
| TRIP4 | Tristetraprolin | TRIT1 | TrkA |
| TRMT2A | TRMT44 | TRMT5 | TRMT6 |
| TROVE2 | TRUB2 | TRX1 | TRβ1 |
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