| Cat.No.: | PE-0975 |
| Product Name: | Recombinant Human Euchromatic Histone-lysine N-methyltransferase 2, GST-tagged |
| Product Overview: | Recombinant human EHMT2 (807-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
| Description: | EHMT2 is a lysine-preferring histone methyltransferase. EHMT2 can methylate itself at K165 and this automethylation is necessary and sufficient to mediate in vivo interaction of EHMT2 with heterochromatin protein-1 (HP1). EHMT2 is responsible for the majority of dimethylation of histone H3 at lysine 9 (H3K9me2) and is required for the efficient repression of developmentally regulated genes during embryonic stem cell differentiation. EHMT2 is overexpressed in various cancers and can can specifically methylate p53 at Lys(373). EHMT2 polymorphisms have been associated with colorectal cancer. |
| Applications: | Western Blot |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 73 kDa |
| Purity: | > 90 % |
| Species: | Human |
| Formulation: | Recombinant protein stored in 50 mM Tris-HCl, ph 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol. |
| Tag: | GST |
| Expression System: | Sf9 Insect Cells |
| Protein Length: | 807-end |
| Concentrations: | 0.1 ug/ul |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | EHMT2 euchromatic histone-lysine N-methyltransferase 2 [ Homo sapiens ] |
| Gene ID NCBI: | 10919 |
| Official Symbol: | EHMT2 |
| Synonyms: | EHMT2; euchromatic histone-lysine N-methyltransferase 2; G9A; BAT8; NG36; KMT1C; C6orf30; FLJ35547; DKFZp686H08213; histone-lysine N-methyltransferase EHMT2; H3-K9-HMTase 3; OTTHUMP00000029262; G9A histone methyltransferase; H3-K9-HMTase 3; HLA-B associated transcript 8; ankyrin repeat-containing protein; histone H3-K9 methyltransferase 3; lysine N-methyltransferase 1C; protein G9a; EC 2.1.1.43 |
| mRNA Refseq: | NM_006709 |
| Protein Refseq: | NP_006700 |
| MIM: | 604599 |
| UniProt ID: | Q96KQ7 |
| Chromosome Location: | 6p21.31 |
| Function: | histone-lysine N-methyltransferase activity; metal ion binding; methyltransferase activity; p53 binding; protein binding; protein-lysine N-methyltransferase activity; transferase activity; zinc ion binding |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0025 | BIX01294 (hydrochloride hydrate) | Inquiry |
| BSM-0026 | UNC0224 | Inquiry |
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Cell Lines | ||
| CL-0059 | Human EHMT1 Knockout Cell Line 7bp deletion | Inquiry |
| CL-0060 | Human EHMT2 Knockout Cell Line 34bp deletion | Inquiry |
| Related Gene / Proteins | |||
| EHD2 | EHMT1 | EHMT2 | |
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