| Cat.No.: | PE-1037 |
| Product Name: | Recombinant Human Protein Arginine Methyltransferase 6, Flag-tagged |
| Product Overview: | Recombinant Human Protein Arginine Methyltransferase 6 (NP_060607.2) (Met 1- Asp 375) was expressed, fused with a Flag tag at the N-terminus. It is expressed in Human Cells. |
| Description: | Protein arginine N-methyltransferase 6, also known as Histone-arginine N-methyltransferase PRMT6, PRMT6, and HRMT1L6, is a member of the protein arginine N-methyltransferase family and PRMT6 subfamily. PRMT6 is highly expressed in kidney and testes. PRMT6 is known to catalyze the generation of asymmetric dimethylarginine in polypeptides. It has been implicated in human immunodeficiency virus pathogenesis, DNA repair, and transcriptional regulation. PRMT6 is known to methylate histone H3 Arg-2 (H3R2), and this negatively regulates the lysine methylation of H3K4 resulting in gene repression. PRMT6 plays a key role in coupling process by functioning as a transcriptional coactivator that can regulate alternative splicing. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | Predictes a molecular mass of 44.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh PRMT6 is approximately 43 - 46 kDa. |
| Purity: | >95 % as determined by SDS-PAGE. |
| Species: | Human |
| Formulation: | Supplied as a 0.2μm filtered solution of PBS, pH 7.5. |
| Tag: | Flag |
| Endotoxin: | < 1.0 EU per 1μg of the protein as determined by the LAL method. |
| Expression System: | Human Cells |
| Protein Length: | 394 amino acids |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | PRMT6 protein arginine methyltransferase 6 [ Homo sapiens ] |
| Gene ID NCBI: | 55170 |
| Synonyms: | PRMT6; protein arginine methyltransferase 6; HRMT1L6; FLJ10559; FLJ51477; EC 2.1.1.125; protein arginine N-methyltransferase 6; Histone-arginine methyltransferase PRMT6; EC 2.1.1.-; Protein arginine N-methyltransferase 6; HMT1 hnRNP methyltransferase-like 6 (S. cerevisiae); Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6 |
| mRNA Refseq: | NM_018137 |
| Protein Refseq: | NP_060607 |
| MIM: | 608274 |
| UniProt ID: | Q96LA8 |
| Chromosome Location: | 1p13.2 |
| Function: | histone binding; transferase activity; protein methyltransferase activity; histone methyltransferase activity (H2A-R3 specific); histone methyltransferase activity (H3-R2 specific); histone methyltransferase activity (H4-R3 specific); protein methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| BSM-0047 | SGC707 | Inquiry |
| ◆ Antibodies | ||
| EAb-0048 | PRMT6 Polyclonal Antibody | Inquiry |
| EAb-0049 | PRMT7 Polyclonal Antibody | Inquiry |
| EAb-0050 | PRMT1 Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| Pr-SET7 | PRC1 | PRC2 | PRDM1 |
| PRDM10 | PRDM11 | PRDM12 | PRDM13 |
| PRDM14 | PRDM15 | PRDM16 | PRDM17 |
| PRDM2 | PRDM3 | PRDM4 | PRDM5 |
| PRDM6 | PRDM7 | PRDM8 | PRDM9 More > |
| PREP1 | PRIM2 | PRKAA2 | PRKCA |
| PRKCB | PRKCE | PRKDC | PRKRIP1 |
| PRMT | prmt1 | PRMT2 | PRMT3 |
| PRMT5 | prmt6 | PRMT7 | PRMT8 |
| PRMT9 | Progerin | Protamine 2 | Prox1 |
| PRPF31 | PRPF40A | PRSS12 | PRSS55 |
| PRTFDC1 | |||
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