| Cat.No.: | PE-1089 |
| Product Name: | Recombinant Human KMT2A protein, GST-tagged, Active |
| Product Overview: | Recombinant Human KMT2A(3738-end) fused with GST tag at N-terminal was expressed in Insect cells. |
| Description: | Histone-lysine N-methyltransferase 2A also known as mixed-lineage leukemia 1 (MLL1) methylates histone H3 on lysine 4 (H3K4) to promote genome accessibility and transcription. Dysregulation or mutation of the KMT2 family have been found in human cancer, exemplified by the initial discovery of KMT2A rearrangements as causes of MLL. |
| Applications: | Methyltransferase Assay |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 52 kDa |
| Purity: | >90% |
| Species: | Human |
| Formulation: | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Tag: | GST |
| Activity: | 600 nmol/min/mg |
| Expression System: | Insect Cells |
| Protein Length: | 3738-end |
| Concentrations: | 0.1μg/μl |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | KMT2A lysine methyltransferase 2A [ Homo sapiens ] |
| Gene ID NCBI: | 4297 |
| Official Symbol: | KMT2A |
| Synonyms: | HRX; MLL; MLL1; TRX1; ALL-1; CXXC7; HTRX1; MLL1A; WDSTS; MLL-AF9; MLL/GAS7; TET1-MLL; CDK6/MLL fusion protein; CXXC-type zinc finger protein 7; MLL-AF4 der(11) fusion protein; MLL/ENL fusion protein; MLL/GAS7 fusion protein; MLL/GMPS fusion protein; MLL/h |
| mRNA Refseq: | NM_005933 |
| Protein Refseq: | NP_005924 |
| MIM: | 159555 |
| UniProt ID: | Q03164 |
| Chromosome Location: | 11q23.3 |
| Function: | AT DNA binding; chromatin binding; histone-lysine N-methyltransferase activity |
| Product Types | ||
| ◆ Synthetic Peptides | ||
| SP-0172 | Human KMT2C / MLL3 peptide | Inquiry |
| ◆ Cell Lines | ||
| CL-0216 | Human KMT2A Knockout Cell Line 32bp deletion | Inquiry |
| CL-0475 | Human KMT2A Knockout Cell Line 32bp deletion | Inquiry |
| ◆ Research Kits | ||
| EKIT-0477 | SMYD2 (KMT3C) Chemiluminescent Assay Kit | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-1085 | Recombinant Human KMT2A, GST-tagged | Inquiry |
| Related Gene / Proteins | |||
| KMT1B | KMT1E | KMT2A | KMT2B |
| KMT2C | KMT2D | KMT2E | KMT3A |
| KMT3B | KMT3C | KMT5A | KMT6 |
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