Cat.No.: | PE-1120 |
Product Name: | Recombinant Human NCOA1, Receptor Interacting Domain |
Description: | Steroid receptor coactivator 1 (SRC1) is a transcriptional coactivoator that mediates the activating functions of many of the nuclear hormone receptors. It is also known as NCoA1 and is a member of the SRC/p160 coactivator family. SRC1 is a 160 kDa protein that contains several LXXLL motifs, which are involved in nuclear receptor interaction. The region 627-786 contains 3 LXXLL motifs that are involved in interaction with nuclear hormone receptors and has been previously used in assays detecting ligand-dependent receptor-cofactor interactions. |
Applications: | Use only for research and not for drug or diagnostic purposes. Recombinant SCR1 (627-786) can be used for protein-protein interaction assays. |
Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
Purity: | > 95% by SDS-PAGE. |
Species: | Human |
Formulation: | Liquid. Supplied in 20 mM Tris-HCl pH 8.0, 100 mM KCl, 0.2 mM EDTA, 1 mM DTT and 20% glycerol. |
Activity: | 100 ng are sufficient for a protein-protein interaction assay. |
Expression System: | E. coli |
Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Gene Name: | NCOA1 nuclear receptor coactivator 1 [ Homo sapiens ] |
Gene ID NCBI: | 8648 |
Synonyms: | NCOA1; nuclear receptor coactivator 1; SRC1; KAT13A; RIP160; F-SRC-1; bHLHe42; bHLHe74; MGC129719; MGC129720; Hin-2 protein; OTTHUMP00000155181; OTTHUMP00000155182; PAX3/NCOA1 fusion protein; steroid receptor coactivator-1; EC 2.3.1.48; OTTHUMP00000155183; NCoA-1; RIP160; SRC-1; Protein Hin-2; Renal carcinoma antigen NY-REN-52; Steroid receptor coactivator 1; nuclear receptor coactivator 1 |
mRNA Refseq: | NM_003743 |
Protein Refseq: | NP_003734 |
MIM: | 602691 |
UniProt ID: | Q15788 |
Chromosome Location: | 2p23 |
Function: | DNA binding; acyltransferase activity; androgen receptor binding; chromatin binding; histone acetyltransferase activity; nuclear hormone receptor binding; protein N-terminus binding; signal transducer activity; transcription coactivator activity; transcription regulator activity; transferase activity |
Product Types | ||
◆ Research Kits | ||
EKIT-0046 | HDAC3/NCOR1 fluorometric drug discovery Kit | Inquiry |
◆ Proteins & Enzymes | ||
PE-0046 | Recombinant Human NCOR1, GST-tagged | Inquiry |
◆ Antibodies | ||
EAb-0065 | NCOA1 Polyclonal Antibody | Inquiry |
◆ Extracts & Lysates | ||
EL-0143 | Recombinant Human NCOA1 293 Cell Lysate | Inquiry |
EL-0144 | Recombinant Human NCOA2 293 Cell Lysate | Inquiry |
Related Gene / Proteins | |||
NCAPD3 | NCAPH2 | NCOA1 | NCOA2 |
NCOA3 | NCoA4 | NCOR1 | ncor2 |
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