| Cat.No.: | PE-1238 |
| Product Name: | Recombinant Human EP300 |
| Product Overview: | Recombinant fragment, corresponding to amino acids 302-531 of human KAT3B / p300 expressed in a bacterial system; 229 amino acids, 25kDa. |
| Description: | This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Sequence Similarities: | Contains 1 bromo domain.Contains 1 KIX domain.Contains 2 TAZ-type zinc fingers.Contains 1 ZZ-type zinc finger. |
| Activity: | 1 unit equals 1 nanogram of purified protein. |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | EP300 E1A binding protein p300 [ Homo sapiens ] |
| Gene ID NCBI: | 2033 |
| Official Symbol: | EP300 |
| Synonyms: | EP300; E1A binding protein p300; histone acetyltransferase p300; KAT3B; p300; |
| mRNA Refseq: | NM_001429 |
| Protein Refseq: | NP_001420 |
| MIM: | 602700 |
| UniProt ID: | Q09472 |
| Chromosome Location: | 22q13.2 |
| Function: | DNA binding; NF-kappaB binding; RNA polymerase II activating transcription factor binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding; acetyltransferase activity; |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0038 | CTPB | Inquiry |
| BSM-0073 | Anacardic Acid | Inquiry |
| BSM-0094 | C646 | Inquiry |
| BSM-0108 | Curcumin, Curcuma longa (High Purity) | Inquiry |
| ◆ Cell Lines | ||
| CL-0061 | Human EP300 Knockout Cell Line 13bp deletion | Inquiry |
| Related Gene / Proteins | |||
| EP300 | EPC1 | ||
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