| Cat.No.: | PE-1250 |
| Product Name: | Recombinant Human KAT6B , GST-tagged |
| Product Overview: | Recombinant human KAT6B (MYST4) (657-1069; contains the catalytic domain) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
| Description: | KAT6B is the catalytic subunit of the histone acetyltransferase (HAT) elongator complex, which is ubiquitously expressed in adult human tissues. KAT6B is a 1,781aa-residue protein that contains a strong transcriptional repression domain at its N terminus and a highly potent activation domain at its C terminus. These domains of KAT6B may be involved in both positive and negative regulation of transcription and also involved in cerebral cortex development. KAT6B is important for cellular aging, proliferation, positive and negative transcriptional regulation and DNA damage repair. |
| Applications: | Western Blot |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | ~76 kDa |
| Purity: | >95% |
| Species: | Human |
| Formulation: | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Tag: | GST |
| Expression System: | Sf9 Insect Cells |
| Protein Length: | 657-1069 aa; contains the catalytic domain |
| Concentrations: | 0.1 μg/μ |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | KAT6B K(lysine) acetyltransferase 6B [ Homo sapiens ] |
| Gene ID NCBI: | 23522 |
| Synonyms: | KAT6B; K(lysine) acetyltransferase 6B; MYST histone acetyltransferase (monocytic leukemia) 4 , MYST4; histone acetyltransferase KAT6B; Morf; MOZ related factor; MOZ2; qkf; querkopf; MYST-4; MOZ-related factor; histone acetyltransferase MORF; histone acetyltransferase MOZ2; histone acetyltransferase MYST4; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4; MYST histone acetyltransferase (monocytic leukemia) 4; monocytic leukemia zinc finger protein-related factor; MORF; GTPTS; MYST4; FLJ90335; KIAA0383; DKFZp313G1618; |
| mRNA Refseq: | NM_001256468 |
| Protein Refseq: | NP_001243397 |
| MIM: | 605880 |
| UniProt ID: | Q8WYB5 |
| Chromosome Location: | 10q22.2 |
| Function: | DNA binding; acetyltransferase activity; histone acetyltransferase activity; metal ion binding; protein binding; transcription factor binding; zinc ion binding; |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0073 | Anacardic Acid | Inquiry |
| ◆ Antibodies | ||
| EAb-0073 | KAT8 Polyclonal Antibody | Inquiry |
| ◆ Cell Lines | ||
| CL-0083 | Human KAT2A Knockout Cell Line 1bp insertion | Inquiry |
| CL-0085 | Human KAT2B Knockout Cell Line 31bp deletion | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0159 | Recombinant Human MYST2 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| Kaiso | KANSL2 | KAP1 | KAT13A |
| KAT13D | KAT2A | KAT2B | KAT4 |
| KAT5 | KAT6A | KAT6B | KAT7 |
| KAT8 | KAT9 | ||
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