| Cat.No.: | PE-1271 |
| Product Name: | Recombinant Human Histone Cluster 1, H3a |
| Product Overview: | Recombinant HumanHIST1H3A (Met 1-Pro 114), was expressed in E.coli. |
| Description: | Histone H3.1, also known as HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J, is a member of the histone H3 family which is a core component of nucleosome. It is expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | Predicts a molecular mass of 15.5 kDa as estimated in SDS-PAGE under reducing conditions. |
| Purity: | > 95% as determined by SDS-PAGE. |
| Species: | Human |
| Formulation: | Lyophilized from sterile 2mM β-Mercaptoethanol. |
| Endotoxin: | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Expression System: | E. coli |
| Protein Length: | 136 amino acids |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | HIST1H3A histone cluster 1, H3a [ Homo sapiens ] |
| Gene ID NCBI: | 8350 |
| Synonyms: | histone cluster 1, H3a; H3/A; H3FA; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; HIST1H3A; histone H3.1; histone H3/a; histone H3/b; histone H3/c; histone H3/d; histone H3/f; histone H3/h; histone H3/I; histone H3/j; histone H3/k; histone H3/l; histone 1, H3a; H3 histone family, member A; Histone H3/l; Histone H3/a; Histone H3/j; Histone H3/k; Histone H3/f; Histone H3/d; Histone H3/I; Histone H3/b; Histone H3/c; Histone H3/h; H3FI; H3FJ; H3FH; H3FF; H3FB; H3FL; H3FC; H3FK; H3FD |
| mRNA Refseq: | NM_003529 |
| Protein Refseq: | NP_003520 |
| MIM: | 602810 |
| UniProt ID: | P68431 |
| Chromosome Location: | 6p21.3 |
| Product Types | ||
| ◆ Nucleosomes | ||
| NUC-0007 | Recombinant Tetranucleosomes H3.3 | Inquiry |
| NUC-0008 | Recombinant Mononucleosomes H3.3 | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0009 | Histone H4 peptide (1-21), Biotin-labeled | Inquiry |
| SP-0010 | Histone H4 peptide (1-21) | Inquiry |
| SP-0012 | Histone H3 peptide (21-44), Biotin-labeled | Inquiry |
| Related Gene / Proteins | |||
| HIC1 | HIF1A | HIF1AN | HINFP |
| HIPK1 | HIPK2 | HIRA | Histone |
| Histone H1 | Histone H2A | Histone H2B | Histone H3 |
| Histone H4 | HIV-1 reverse transcriptase | ||
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