| Cat.No.: | PE-1486 |
| Product Name: | Recombinant Human PRDM16 protein, MYC/DDK-tagged |
| Product Overview: | Recombinant Human PRDM16 fused with MYC/DDK tag at C-terminal was expressed in HEK293. |
| Description: | The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 140.1 kDa |
| Purity: | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Species: | Human |
| Formulation: | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Tag: | MYC/DDK |
| Expression System: | HEK293 |
| Concentrations: | >50 ug/mL as determined by microplate BCA method |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | PRDM16 PR domain containing 16 [ Homo sapiens ] |
| Gene ID NCBI: | 63976 |
| Official Symbol: | PRDM16 |
| Synonyms: | PRDM16; PR domain containing 16; PR domain zinc finger protein 16; KIAA1675; MDS1/EVI1 like; MEL1; MGC166915; PFM13; transcription factor MEL1; MDS1/EVI1-like gene 1; |
| mRNA Refseq: | NM_022114 |
| Protein Refseq: | NP_071397 |
| MIM: | 605557 |
| UniProt ID: | Q9HAZ2 |
| Chromosome Location: | 1p36.23-p33 |
| Function: | SMAD binding; metal ion binding; protein binding; sequence-specific DNA binding; transcription coactivator activity; zinc ion binding; |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| BSM-0047 | SGC707 | Inquiry |
| ◆ Antibodies | ||
| EAb-0048 | PRMT6 Polyclonal Antibody | Inquiry |
| EAb-0049 | PRMT7 Polyclonal Antibody | Inquiry |
| EAb-0050 | PRMT1 Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| Pr-SET7 | PRC1 | PRC2 | PRDM1 |
| PRDM10 | PRDM11 | PRDM12 | PRDM13 |
| PRDM14 | PRDM15 | PRDM16 | PRDM17 |
| PRDM2 | PRDM3 | PRDM4 | PRDM5 |
| PRDM6 | PRDM7 | PRDM8 | PRDM9 More > |
| PREP1 | PRIM2 | PRKAA2 | PRKCA |
| PRKCB | PRKCE | PRKDC | PRKRIP1 |
| PRMT | prmt1 | PRMT2 | PRMT3 |
| PRMT5 | prmt6 | PRMT7 | PRMT8 |
| PRMT9 | Progerin | Protamine 2 | Prox1 |
| PRPF31 | PRPF40A | PRSS12 | PRSS55 |
| PRTFDC1 | |||
USA
Enter your email here to subscribe.
Follow us on
Easy access to products and services you need from our library via powerful searching tools
