| Cat.No.: | SP-0021 |
| Product Name: | Fluorogenic SIRT substrate 1 |
| Product Overview: | A fluorogenic, acetylated peptide substrate for SIRTs. It is a suitable substrate for SIRT1, SIRT2 and SIRT3. The substrate is based on residues 379-382 (Arg-His-Lys-Lys) of p53, a site of regulatory acetylation by the p300 and CBP acetyltransferases on lysines 381 and 382. This substrate fluoresces at excitation 350-380 nm, emission at 440-460 nm. |
| Applications: | Study enzyme kinetics, and screen small molecule sirtuin inhibitors for drug discovery and HTS applications. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Format: | DMSO solution |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0016 | Recombinant Human SIRT1 Lysate | Inquiry |
| EL-0017 | Recombinant Human SIRT2 293 Cell Lysate | Inquiry |
| EL-0018 | Recombinant Human SIRT3 293 Cell Lysate | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0017 | Fluorogenic Sirtuin 5 Substrate | Inquiry |
| SP-0018 | Fluorogenic Sirtuin 6 Substrate | Inquiry |
| Related Gene / Proteins | |||
| Siah2 | SIK1 | SIMC1 | SIN3A |
| SIN3B | SIP1 | Sir2p | SIRT |
| SIRT1 | SIRT2 | SIRT3 | SIRT4 |
| SIRT5 | sirt6 | SIRT7 | SIX3 |
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