| Cat.No.: | PE-1899 |
| Product Name: | UTX (human recombinant) |
| Description: | Ubiquitously transcribed tetratricopeptide repeat X (UTX) gene codes for the widely-expressed UTX protein. The UTX gene is localized on the X chromosome and is a homolog of the ubiquitously transcribed mouse Y chromosome (UTY) gene. UTX gene expression has been shown to evade X-chromosome inactivation. The JmjC-containing UTX protein is a member of the hydroxylase family of enzymes, which are α-ketoglutarate-dependent Fe (II) oxygenases. UTX plays a crucial role in epigenetic regulation of gene expression by catalyzing the demethylation of tri-methylated lysine 27 on histone H3. UTX works in opposition to the polycomb repressive complex 2 (PRC2) group protein EZH2, playing a role in cancers with abberant H3K27 methylation. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 70.5 kDa |
| Purity: | ≥70% (by SDS-PAGE) |
| Species: | human |
| Formulation: | 50 mM Hepes, pH 7.4, containing 150 mM sodium chloride and 20% glycerol |
| Accession#: | O15550 |
| Alternative Names: | KDM6A;Ubiquitously Transcribed Tetratricopeptide Repeat X |
| Expression System: | E. coli |
| Protein Length: | 930-1,410 (N-terminal truncation) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0096 | Caffeic acid | Inquiry |
| BSM-0137 | GSK-J1 (Free acid) | Inquiry |
| BSM-0138 | GSK-J1 sodium salt | Inquiry |
| BSM-0139 | GSK-J4 (Free base) | Inquiry |
| BSM-0140 | GSK-J4 hydrochloride | Inquiry |
| Related Gene / Proteins | |||
| UTF1 | UTX | ||
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