| Cat.No.: | PE-2005 |
| Product Name: | HDAC8 Protein, Human, Recombinant (GST Tag) |
| Product Overview: | Full length of human HDAC8 isoform 1 (NP_060956.1) (Met 1-Val 377) fused with the GST tag at the C-terminus. |
| Background: | Histone deacetylase 8, also known as HDAC8 and HDACL1, is a nucleus and cytoplasm protein which belongs to thehistone deacetylase family and HD type 1 subfamily. Histone deacetylases (HDACs) are a growing family of enzymes implicated in transcriptional regulation by affecting the acetylation state of core histones in the nucleus of cells.HDAC8 / HDACL1 is weakly expressed in most tissues. It expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney. HDAC8 / HDACL1 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones ( H2A, H2B, H3 and H4 ). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC8 / HDACL1 may play a role in smooth muscle cell contractility. HDAC8 / HDACL1 may be a potential drug target for neuroblastoma differentiation therapy using selective inhibitors, avoiding unspecific side effects. |
| Applications: | ELISA; Western Blot , Enzyme activity assay |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | The recombinant human HDAC8/GST chimera consists of 602 amino acids and has a predicted a molecular mass of 68 kDa as estimated in SDS-PAGE under reducing conditions. |
| Purity: | > 88 % as determined by SDS-PAGE |
| Species: | Human |
| Formulation: | Lyophilized from sterile 50mM Tris, 100mM NaCl, 0.5mM PMSF, 10% glycerol, pH 8.01. |
| Accession#: | NP_060956.1 |
| Alternative Names: | CDA07 Protein, Human; CDLS5 Protein, Human; HD8 Protein, Human; HDACL1 Protein, Human; MRXS6 Protein, Human; RPD3 Protein, Human; WTS Protein, Human |
| Tag: | GST |
| Endotoxin: | < 1.0 EU per μg of the protein as determined by the LAL method |
| Expression System: | Baculovirus-Insect Cells |
| Common Name: | histone deacetylase 8 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
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