| Cat.No.: | PE-2038 |
| Product Name: | SUV420H2 Protein, Human, Recombinant (His & GST Tag) |
| Product Overview: | Amino acid sequence (Gly 2-Leu 280) of human SUV420H2 (NP_116090.2) fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus. |
| Background: | Histone-lysine N-methyltransferase SUV42H2, also known as Suppressor of variegation 4-2 homolog 2, Su(var)4-2 homolog 2, Lysine N-methyltransferase 5C, SUV42H2 and KMT5C, is nucleus protein which belongs to thehistone-lysine methyltransferase family and Suvar4-2 subfamily. SUV42H2 is a histone methyltransferase that specifically trimethylates 'Lys-2' of histone H4. H4 'Lys-2' trimethylation represents a specific tag for epigenetic transcriptional repression. SUV42H2 mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV42H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). FRAP experiments reveal that SUV42H2 is strongly associated to pericentric heterochromatin. The fraction of SUV42H2 captured and characterized by TAP/MS is a soluble fraction which may be in a stable association with HP1. SUV42H2 may be recruited to heterochromatin in association with HP1, and stably maintained at its heterochromatin sites in an HP1-independent fashion. |
| Applications: | ELISA; Western Blot , Enzyme activity assay |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | The recombinant human SUV420H2/GST chimera consists of 516 amino acids and has a calculated molecular mass of 60 kDa as estimated in SDS-PAGE under reducing conditions. |
| Purity: | > 80 % as determined by SDS-PAGE |
| Species: | Human |
| Formulation: | Lyophilized from sterile 50mM Tris, 0.5M NaCl, 30% Glycerol, 0.05% Teween, pH 8.01. |
| Accession#: | NP_116090.2 |
| Alternative Names: | KMT5C Protein, Human |
| Tag: | His & GST |
| Expression System: | E. coli |
| Common Name: | suppressor of variegation 4-20 homolog 2 (Drosophila) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0020 | Suz12 Polyclonal Antibody | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0100 | Chaetocin | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0103 | Recombinant Human SUZ12 293 Cell Lysate | Inquiry |
| EL-0132 | Recombinant Human SUV39H1 293 Cell Lysate | Inquiry |
| EL-0137 | Recombinant Human SUV420H1 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| SUDS3 | SUMO | SUMO1 | SUMO2 |
| SUMO3 | SUN1 | Surf6 | suv39h1 |
| SUV39H2 | SUV3L1 | SUV420H1 | SUV420H2 |
| SUZ12 | |||
USA
Enter your email here to subscribe.
Follow us on
Easy access to products and services you need from our library via powerful searching tools
