| Cat.No.: | PE-2044 |
| Product Name: | KDM4B protein-GST fusion |
| Background: | KDM4B or lysine (K)-specific demethylase 4B, which is also known as JMJD2B, contains a JmjN domain, a JmjC domain, a JD2H domain, 2 TUDOR domains, and a bipartite nuclear localization signal that overlaps the C-terminal part of the second TUDOR domain. KDM4B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6. KDM4B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development. KDM4B is regulated by both ERa and HIF-1a, drives breast cancer cell proliferation in normoxia and hypoxia, and epigenetically regulates the expression of cell cycle genes such as CCND1, CCNA1, and WEE1. |
| Applications: | KDM4B Protein is suitable for use in Western Blot. Expect a band approximately ~125kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid (sterile filtered) |
| Purity: | >75% by densitometry |
| Species: | Mouse |
| Formulation: | 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol |
| Accession#: | NM_172132.2 |
| Alternative Names: | Jmjd2b, mKIAA0876, 4732474L06Rik, Lysine-specific demethylase 4B, EC 1.14.11.-, JmjC domain-containing histone demethylation protein 3B, Jumonji domain-containing protein 2B |
| Tag: | GST |
| Expression System: | Sf9 Insect Cells |
| Protein Length: | 1-725 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0015 | Human KDM5B Knockout Cell Line 14bp deletion | Inquiry |
| CL-0087 | Human KDM1A Knockout Cell Line 10bp deletion | Inquiry |
| CL-0088 | Human KDM1B Knockout Cell Line 13bp deletion | Inquiry |
| CL-0089 | Human KDM2B Knockout Cell Line 14bp deletion | Inquiry |
| ◆ Antibodies | ||
| EAb-0071 | KDM1B Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| KDM1 | KDM1A | KDM1B | KDM2 |
| KDM2A | KDM2B | KDM3A | KDM3B |
| KDM4 | KDM4A | KDM4B | KDM4C |
| KDM4D | KDM4E | KDM5 | KDM5A |
| KDM5B | KDM5C | KDM5D | KDM6A More > |
| KDM6B | KDM6C | KDM7 | KDM7A |
| KDM7B | KDM8 | ||
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