Cat.No.: | EAb-0071 |
Product Name: | KDM1B Polyclonal Antibody |
Product Overview: | Polyclonal Antibody to detect KDM1B in human samples. |
Antibody Type: | Polyclonal |
Immunogen: | Polyclonal antibody raised in rabbit against human KDM1B (lysine (K)-specific demethylase 1B) using two KLH conjugated synthetic peptides containing a sequence from the N-terminal and the central region of the protein, respectively. |
Host: | Rabbit |
Isotype: | IgG |
Antibody Target: | KDM1B |
Purification: | Whole Anti-Sera |
Appearance: | Colorless liquid |
Formulation: | In PBS with 0.05% (W/V) sodium azide. |
Applications: | ELISA. |
Recommended Dilutions/Conditions: |
ELISA: 1:500. Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
Positive Control: | ELISA: Peptides. |
Species Reactivity: | Human |
Shipping: | Gel Pack |
Storage: | -20°C |
Warning: | For Research Use Only! Not For Use in Humans. |
Accession: | Q8NB78 |
Alternative Name: | AOF1, LSD2, C6orf193 |
Scientific Background: | KDM1B is a histone demethylase that demethylates lysine 4 of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. KDM1B is able to demethylate both mono- and di-methylated lysine 4 of histone H3, but has no effect on tri-methylated lysine 4, mono-, di- or tri-methylated lysine 9, mono-, di- or tri-methylated lysine 27, mono-, di- or tri-methylated lysine 36 of histone H3, or on mono-, di- or tri-methylated lysine 20 of histone H4. KDM1B is also required for de novo DNA methylation of a subset of imprinted genes during oogenesis. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. |
Product Types | ||
◆ Cell Lines | ||
CL-0015 | Human KDM5B Knockout Cell Line 14bp deletion | Inquiry |
CL-0087 | Human KDM1A Knockout Cell Line 10bp deletion | Inquiry |
CL-0088 | Human KDM1B Knockout Cell Line 13bp deletion | Inquiry |
CL-0089 | Human KDM2B Knockout Cell Line 14bp deletion | Inquiry |
◆ Antibodies | ||
EAb-0071 | KDM1B Polyclonal Antibody | Inquiry |
Related Gene / Proteins | |||
KDM1 | KDM1A | KDM1B | KDM2 |
KDM2A | KDM2B | KDM3A | KDM3B |
KDM4 | KDM4A | KDM4B | KDM4C |
KDM4D | KDM4E | KDM5 | KDM5A |
KDM5B | KDM5C | KDM5D | KDM6A More > |
KDM6B | KDM6C | KDM7 | KDM7A |
KDM7B | KDM8 |
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