| Cat.No.: | PE-2049 |
| Product Name: | Recombinant human KDM4B / JMJD2B protein |
| Background: | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. |
| Applications: | Functional Studies; SDS-PAGE |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Molecular Weight: | 57 kDa including tags |
| Purity: | >41 % SDS-PAGE. |
| Species: | Human |
| Formulation: | pH: 8; Constituents: 0.71% Tris HCl, 10% Glycerol, 0.05% DTT, 0.02% Potassium chloride, 0.72% Sodium chloride |
| Accession#: | O94953 |
| Alternative Names: | JHDM3B/JmjC domain-containing histone demethylation protein 3B/JMJD2B |
| Tag: | DDDDK |
| Amino Acid Sequence: | MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIP PKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRR LANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWN IGSLRTILDMVERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINY LHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPII LKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDY GKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTAL TSPELSSWSASRASLKAKLLRRSHRKRSQPKKPKPEDPKFPGEGTAGAAL LEEAGGSVKEEAGPEVDPEEEEEEPQPLPHGREAEGAEEDGRGKLRPTKA KSERKKKSFGLLPPQLPPPPAHFPSEEALWLPSPLEPPVLGPGPAAMEES |
| Sequence Similarities: | Belongs to the JHDM3 histone demethylase family.Contains 1 JmjC domain.Contains 1 JmjN domain.Contains 2 PHD-type zinc fingers.Contains 2 Tudor domains. |
| Expression System: | Sf9 Insect Cells |
| Protein Length: | Protein fragment; 1 to 500 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0015 | Human KDM5B Knockout Cell Line 14bp deletion | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Antibodies | ||
| EAb-0071 | KDM1B Polyclonal Antibody | Inquiry |
| EAb-0072 | JMJD6 Polyclonal Antibody | Inquiry |
| EAb-0074 | JMJD2c Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| JMJD | JMJD1A | JMJD1B | JMJD1C |
| JMJD2 | JMJD2A | JMJD2B | JMJD2C |
| JMJD2D | JMJD2E | JMJD2F | JMJD3 |
| JMJD4 | JMJD5 | JMJD6 | KDM1 |
| KDM1A | KDM1B | KDM2 | KDM2A More > |
| KDM2B | KDM3A | KDM3B | KDM4 |
| KDM4A | KDM4B | KDM4C | KDM4D |
| KDM4E | KDM5 | KDM5A | KDM5B |
| KDM5C | KDM5D | KDM6A | KDM6B |
| KDM6C | KDM7 | KDM7A | KDM7B |
| KDM8 | |||
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