Recombinant human PARP3/IRT1 protein

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Cat.No.:  PE-2084
Product Name:  Recombinant human PARP3/IRT1 protein
Background:  Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
Applications:  Functional Studies; SDS-PAGE
Storage:  Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles.
Appearance:  Liquid
Species:  Human
Formulation:  pH: 8.00; Constituents: 0.0462% DTT, 0.395% Tris HCl, 0.05% Tween, 50% Glycerol, 0.58% Sodium chloride
Alternative Names:  ADP ribosyltransferase (NAD+; poly (ADP ribose)/ADP ribosyltransferase diphtheria toxin like 3/ADPRT-3
Sequence Similarities:  Contains 1 PARP alpha-helical domain.Contains 1 PARP catalytic domain.
Expression System:  Sf9 Insect Cells
Post Translational Modifications:  Auto-poly(ADP)-ribosylation.
Protein Length:  Full length protein
Warning:  This product is for research use only. Not for use in diagnostic or therapeutic procedures.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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