Recombinant Human HDAC2 protein


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Cat.No.:  PE-2338
Product Name:  Recombinant Human HDAC2 protein
Background:  Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity.
Applications:  Western blot; Functional Studies
Storage:  Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles.
Appearance:  Liquid
Molecular Weight:  92 kDa including tags
Purity:  > 70 % SDS-PAGE.
Species:  Human
Formulation:  pH: 7.50; Constituents: 0.307% Glutathione, 0.00174% PMSF, 0.00385% DTT, 0.79% Tris HCl, 0.00292% EDTA, 25% Glycerol, 0.87% Sodium chloride
Accession#:  Q92769
Alternative Names:  D10Wsu179e/HD 2/HD2
Sequence Similarities:  Belongs to the histone deacetylase family. HD type 1 subfamily.
Expression System:  Baculovirus
Post Translational Modifications:  S-nitrosylated by GAPDH. In neurons, S-Nitrosylation at Cys-262 and Cys-274 does not affect the enzyme activity but abolishes chromatin-binding, leading to increases acetylation of histones and activate genes that are associated with neuronal development. In embryonic cortical neurons, S-Nitrosylation regulates dendritic growth and branching.
Protein Length:  Full length protein; 1 to 488
Warning:  This product is for research use only. Not for use in diagnostic or therapeutic procedures.

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