| Cat.No.: | PE-2465 |
| Product Name: | Recombinant Human NIPP1 protein |
| Background: | Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing. |
| Applications: | SDS-PAGE; Mass Spectrometry |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Molecular Weight: | 40 kDa including tags |
| Purity: | > 90 % SDS-PAGE. Purified using conventional chromatography techniques |
| Species: | Human |
| Formulation: | pH: 8.00; Constituents: 0.03% DTT, 0.32% Tris HCl, 20% Glycerol, 1.17% Sodium chloride |
| Accession#: | Q12972 |
| Alternative Names: | Activator of RNA decay/ARD 1/ARD-1 |
| Tag: | His |
| Amino Acid Sequence: | MAAAANSGSS LPLFDCPTWA GKPPPGLHLD VVKGDKLIEK LIIDEKKYYL FGRNPDLCDF TIDHQSCSRV HAALVYHKHL KRVFLIDLNS THGTFLGHIR LEPHKPQQIP IDSTVSFGAS TRAYTLREKP QTLPSAVKGD EKMGGEDDEL KGLLGLPEEE TELDNLTEFN TAHNKRISTL TIEEGNLDIQ RPKRKRKNSR VTFSEDDEII NPEDVDPSVG RFRNMVQTAV VPVKKKRVEG PGSLGLEESG SRRMQNFAFS GGLYGGLPPT HSEAGSQPHG IHGTALIGGL PMPYPNLAPD VDLTPVVPSA VNMNPAPNPA VYNPEAVNEP KKKKYAKEAW PGKKPTPSLL IVEHHHHHH |
| Sequence Similarities: | Contains 1 FHA domain. |
| Expression System: | E. coli |
| Post Translational Modifications: | May be inactivated by phosphorylation on Ser-199 or Ser-204 (By similarity). Phosphorylated by Lyn in vitro on Tyr-264, and also on Tyr-335 in the presence of RNA. |
| Protein Length: | Full length protein; 1 to 351 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0192 | Human NIPA1 Knockout Cell Line | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0550 | Recombinant Human NIPBL, GST-tagged | Inquiry |
| PE-0551 | Recombinant Mouse NIPBL Protein | Inquiry |
| PE-2465 | Recombinant Human NIPP1 protein | Inquiry |
| PE-2622 | Recombinant Human NIPP1 protein | Inquiry |
| Related Gene / Proteins | |||
| NIP7 | NIPA1 | NIPBL | NIPP1 |
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