| Cat.No.: | PE-3475 |
| Product Name: | Recombinant EIF4A2 protein |
| Product Overview: | Recombinant EIF4A2 protein was expressed in E.coli as the full length protein (accession number NP_001958.2) with an N-terminal 6×His-Tag. The molecular weight of the protein is 49.9 kDa. |
| Background: | EIF4A2 (Eukaryotic Translation Initiation Factor 4A, Isoform 2), also called EIF4F or DDX2B, is an ATP dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition. It is required for mRNA binding to the ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5’-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. This protein is involved in the binding of mRNA to 40S subunit of ribosome,ubiquitous with high expression in skeletal muscle and ovary.Diseases associated with EIF4A2 include Retinitis Pigmentosa 29 and X-Linked Hereditary Ataxia. Among its related pathways are the TGFβ pathway and Apoptotic pathways in Synovial Fibroblasts. |
| Applications: | Suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | 25 mM Tris-HCl pH 8.0, 500 mM NaCl, 10% glycerol, and 0.5 mM TCEP. |
| Tag: | His |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Proteins & Enzymes | ||
| PE-2388 | Recombinant Human EID1 protein | Inquiry |
| PE-2389 | Recombinant Human EID1 protein | Inquiry |
| PE-3474 | Recombinant EIF4A3 protein | Inquiry |
| PE-3475 | Recombinant EIF4A2 protein | Inquiry |
| PE-3476 | Recombinant EIF4A1 protein | Inquiry |
| Related Gene / Proteins | |||
| EID1 | EIF4A1 | EIF4A2 | EIF4A3 |
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