| Cat.No.: | PE-3476 |
| Product Name: | Recombinant EIF4A1 protein |
| Product Overview: | Recombinant EIF4A1 protein was expressed in E.coli as the full length protein (accession number NP_001407.1) with an N-terminal 6×His-Tag. The molecular weight of the protein is 49.7 kDa. |
| Background: | EIF4A1 (Eukaryotic Translation Initiation Factor 4A, Isoform 1), also called as EIF4A or DDX2A, is a ATP dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition. It is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5’-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. This protein is involved in the binding of mRNA to 40S subunit of ribosome,ubiquitous with high expression in skeletal muscle and ovary. The helicase activity of EIF4A1 and function in translation are inhibited by interaction with PDCD4. |
| Applications: | Suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | 25 mM Tris-HCl pH 7.4, 300 mM NaCl, 5% glycerol, and 0.1% Triton X-100. |
| Tag: | His |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Proteins & Enzymes | ||
| PE-2388 | Recombinant Human EID1 protein | Inquiry |
| PE-2389 | Recombinant Human EID1 protein | Inquiry |
| PE-3474 | Recombinant EIF4A3 protein | Inquiry |
| PE-3475 | Recombinant EIF4A2 protein | Inquiry |
| PE-3476 | Recombinant EIF4A1 protein | Inquiry |
| Related Gene / Proteins | |||
| EID1 | EIF4A1 | EIF4A2 | EIF4A3 |
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