| Cat.No.: | PE-3821 |
| Product Name: | HDAC3/NCOR1 complex (human), (recombinant) |
| Description: | Approximately 1:1 stoichiometric complex of recombinant human HDAC3 (histone deacetylase 3) with a GST fusion protein comprising the Deacetylase Activation Domain (DAD) of human NCOR1 (amino acids 397-503; SANT1 domain plus amino flanking residues). Produced by coexpression of HDAC3 with a GST-NCOR1(DAD) construct in an insect cell system. |
| Background: | HDAC3, although a class I HDAC, is found in co-repressor complexes with the SMRT/N-CoR proteins, complexes distinct from than those comprising other class I enzymes. It has a unique domain structure, including both nuclear localization and nuclear export sequences and has been assigned to its own phylogenetic subclass. Inhibition of HDAC3 may be the determining factor in the anti-proliferative effects of HDAC inhibitors on cancer cells and its caspase-dependent cleavage and relocation to the cytoplasm may be critical to the progression of apoptosis. It has been shown that HDAC3, rather than the class II HDACs 4 and 5, likely diretly deacetylates MEF2, implying an important role in pathways affecting heart disease. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Molecular Weight: | 49/40 kDa |
| Purity: | ≥90% (SDS-PAGE) |
| Species: | Human |
| Formulation: | 50mM TRIS, pH 8.0, 138 mM NaCl and 10% glycerol. |
| Accession#: | O15379 (HDAC3), O75376 (NCOR1) |
| Alternative Names: | Histone deacetylase 3/Nuclear receptor corepressor 1 |
| Tag: | GST |
| Expression System: | Insect Cells |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
| NCAPD3 | NCAPH2 | NCOA1 | NCOA2 |
| NCOA3 | NCoA4 | NCOR1 | ncor2 |
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