| Cat.No.: | EKIT-0052 |
| Product Name: | HDAC1 Inhibitor Screening Assay Kit |
| Size: | 96 wells |
| Product Overview: | HDAC1 Inhibitor Screening Assay Kit is a fluorescence-based method for screening HDAC1 inhibitors. |
| Description: | Histone deacetylases (HDACs) catalyze the hydrolytic removal of acetyl groups from histone lysine residues resulting in chromatin condensation and transcriptional repression of chromosomal DNA. Thus, HDAC inhibition allows the conformation of DNA to be relaxed and transcriptional activation to ensue. Changes in the transcription of key genes have linked HDAC inhibitors to blocking angiogenesis and cell cycling, and promoting apoptosis and differentiation. HDAC1 Inhibitor Screening Assay Kit provides a fast, fluorescence-based method for screening HDAC1 inhibitors. The procedure requires only two easy steps, both performed in the same microplate. The fluorescent reaction product is easily analyzed using a fluorometer with excitation wavelengths of 340-360 nm and emission wavelengths of 440-465 nm. Sufficient purified HDAC1 is provided for 100 tests. |
| Kit Components: | HDAC Assay Buffer (10X) 1 vialHDAC1 (human recombinant) 1 vialHDAC Trichostatin A 1 vialHDAC Substrate 1 vial96-Well Plate (Black) 1 plateHDAC Developer 2 vials96-Well Cover Sheet 1 cover |
| Storage: | This kit will perform as specified if stored as directed at -80°C and used before the expiration date indicated on the outside of the box.HDAC Assay Buffer (10X) -20°CHDAC1 (human recombinant) -80°CHDAC Trichostatin A -20°CHDAC Substrate -20°C96-Well Plate (Black) Room temperatureHDAC Developer -20°C96-Well Cover Sheet Room temperature |
| Warning: | For research use only, not for diagnostic use. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
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