PHA-680632


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  • Related Products
Cat.No.:  BSM-0003
Product Name:  PHA-680632
CAS No.:  398493-79-3
Molecular Weight:  501.62
Purity:  >99%
Storage:  2 years at -20°C
Targets:  Aurora A
Molecular Formula:  C28H35N7O2
Solubility:  No
In Vitro PHA-680632 potently inhibits all three Aurora kinases (A, B, and C) with IC50 values of 27, 135, and 120 nM, respectively. PHA-680632 (0.5 uM) causes polyploidy in tumor cells. The mechanism of action of PHA-680632 is in agreement with inhibition of Aurora kinases. PHA680632 in association with radiation leads to additive effects in cancer cells, especially in the p53-deficient cells.
Warning:  For Research Use Only! Not For Use in Humans.
Product Types
◆ Bioactive Small Molecules
BSM-0001 KW 2449 Inquiry
BSM-0002 AT9283 Inquiry
BSM-0003 PHA-680632 Inquiry
BSM-0004 TAK-901 Inquiry
BSM-0005 SQ 22536 Inquiry
Related Gene / Proteins
AUH Aurka AurkB AurkC

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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