| Cat.No.: | BSM-0198 |
| Product Name: | Belinostat (PXD101) |
| CAS No.: | 414864-00-9 |
| Figure: |
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| Synonyms: | (E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide; Belinostat |
| Description: | Belinostat is a novel and potent hydroxamate-type HDAC inhibitor. It inhibits HDAC activity in HeLa cell extracts with an IC50 of 27 nM. Belinostat significantly increases acetylation of histones H3 and H4 and potently inhibits the growth of prostate cancer cell lines (IC50 range from 0.5 to 2.5 µM) with cytotoxic activity preferentially against tumor cells. |
| Appearance: | White solid |
| Molecular Weight: | 318.35 |
| Purity: | ≥98% by HPLC |
| Storage: | -20°C |
| Targets: | Histone deacetylase (HDAC) activity |
| Molecular Formula: | C15H14N2O4S |
| MDL Number: | MFCD18086851 |
| Solubility: | DMSO (>50 mg/ml) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
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