| Cat.No.: | BSM-0201 |
| Product Name: | Remodelin |
| CAS No.: | 949912-58-7 |
| Figure: |
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| Synonyms: | 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile |
| Description: | Remodelin is a potent and selective inhibitor of the acetyl-transferase protein NAT10 that mediates nuclear shape rescue in laminopathic (LMNA-depleted) cells via microtubule reorganization. Remodelin markedly reduces the prevalence of misshapen nuclei in HGPS cells as well as in primary MRC5 fibroblasts aged in culture. In contrast, Remodelin has no effect on nonlaminopathic Werner syndrome cells. |
| Appearance: | White to off-white solid |
| Molecular Weight: | 282.36 |
| Purity: | ≥98% by HPLC |
| Storage: | -20°C |
| Targets: | Acetyl-transferase protein NAT10 |
| Molecular Formula: | C₁₅H₁₄N₄S |
| MDL Number: | MFCD00149487 |
| Solubility: | DMSO (~ 15 mg/ml) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0040 | FK-866 HCl | Inquiry |
| BSM-0201 | Remodelin | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0051 | Recombinant Human NACC2 Cell Lysate | Inquiry |
| EL-0085 | Recombinant Human NAP1L2 293 Cell Lysate | Inquiry |
| EL-0158 | Recombinant Human NASP 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| NAA38 | NAA60 | NACC2 | Nampt |
| Nanog | Nanos3 | Nap1 | NAP1L1 |
| NAP1L2 | NAP1L4 | NARG1 | NASP |
| NAT10 | NAT14 | ||
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