| Cat.No.: | BSM-0380 |
| Product Name: | PAOA |
| CAS No.: | 537034-15-4 |
| Figure: |
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| Synonyms: | Histone Deacetylase Inhibitor IV |
| Product Overview: | A selective HDAC1/3 inhibitor |
| Description: | PAOA is a selective histone deacetylase (HDAC) inhibitor with IC50 values of 199 and 69 nM for HDAC1 and HDAC3, respectively. It is selective for HDAC1 and HDAC3, having IC50 values greater than 1.59 μM for HDAC2, 4, 5, 7, and 8 in a cell-free enzyme assay. In vitro, PAOA induces histone H3 and H4 hyperacetylation. PAOA improves the metabolic deficit exhibited by murine striatal cells isolated from HdhQ111 knock-in mice in a dose-dependent manner and reduces eye neurodegeneration. melanogaster model of Huntington’s disease. In vivo, PAOA prevents formation of Huntingtin (Htt) protein aggregates in the brain and reduces the cognitive deficits in the N171-82Q mouse model of Huntington’s disease. |
| Appearance: | A crystalline solid |
| Molecular Weight: | 325.4 |
| Purity: | ≥95% |
| Storage: | -20°C |
| Targets: | HDAC1; HDAC3 |
| Molecular Formula: | C19H23N3O2 |
| Chemical Name: | N1-(2-aminophenyl)-N7-phenyl-heptanediamide |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
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