| Cat.No.: | EAb-0232 |
| Product Name: | Polycomb 2 Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | Synthetic peptide corresponding to a portion of N-terminal human Polycomb 2, conjugated to KLH. |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Affinity purified |
| Appearance: | Liquid |
| Formulation: | In PBS containing 0.09% sodium azide. |
| Applications: | ELISA, IHC, WB |
| Recommended Dilutions/Conditions: |
ELISA (1:1,000)Immunohistochemistry (1:50-1:100)Western Blot (1:100-1:500). Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse |
| Shipping: | Blue Ice |
| Storage: | -20°C |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | O00257 |
| Alternative Name: | E3 SUMO-protein Ligase CBX4, Chromobox Protein Homolog 4, Pc2 |
| Scientific Background: | Polycomb 2 is a member of Drosophila Polycomb group gene family. The polycomb group (PcG) genes are essential for maintenance of proper expression patterns of developmental master regulators; changes in expression pf PcG proteins have been associated with cancer. Polycomb 2 is a part of the cellular memory system responsible for the inheritance of gene activity by progeny cells. It participates in maintaining the transcriptionally repressive state of genes. Polycomb 2 is part of acomplex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Polycomb 2 is an E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0194 | PFI-3 | Inquiry |
| ◆ Antibodies | ||
| EAb-0231 | Polycomb 2 Polyclonal Antibody | Inquiry |
| EAb-0232 | Polycomb 2 Polyclonal Antibody | Inquiry |
| ◆ Cell Lines | ||
| CL-0399 | Human POLB Knockout Cell Line 1bp deletion | Inquiry |
| CL-0407 | Human POLE Knockout Cell Line 2bp deletion | Inquiry |
| Related Gene / Proteins | |||
| POLB | POLE | POLE3 | POLE4 |
| POLG2 | POLH | POLI | POLK |
| POLL | POLM | POLN | POLQ |
| POLR2B | Polybromo 1 | Polycomb 2 | POMP |
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