SUMO Polyclonal Antibody

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Cat.No.:  EAb-0268
Product Name:  SUMO Polyclonal Antibody
Antibody Type:  Polyclonal
Immunogen:  Recombinant yeast Smt3 amino acid 1-97
Host:  Rabbit
Appearance:  Liquid
Formulation:  Affinity-purified polyclonal antibody
Applications:  ELISA and WB
Shipping:  Wet ice
Storage:  -20°C
Storage Buffer:  TBS, pH 7.4 when reconstituted in 500 µl deionized water
Warning:  For Research Use Only! Not For Use in Humans.
Alternative Name:  Small Ubiquitin Like Modifier;Smt3
Scientific Background:  The Small Ubiquitin Like Modifier (SUMO) protein is similar in structure and function to ubiquitin. However, SUMO does not typically target proteins for degradation as does ubiqutin. SUMO is involved with the modification of a very diverse array of targets. Proteins involved with transcriptional regulation, DNA damage repair, genomic stability, nuclear transport, and histone modification are all subject to modification by SUMO. SUMO typically functions by covalently binding to a target protein, followed by regulation of protein:protein and protein:DNA interactions. The SUMO family of proteins is highly conserved from yeast to human. Invertebrates contain a single SUMO gene (Smt3 in yeast and smo-1 in C. elegans), with three members of SUMO being identified in vertebrates to date (SUMO-1, SUMO-2 and SUMO-3).

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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