HDAC7 (Phospho-Ser155) Polyclonal Antibody

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Cat.No.:  EAb-0279
Product Name:  HDAC7 (Phospho-Ser155) Polyclonal Antibody
Antibody Type:  Polyclonal
Immunogen:  synthetic peptide from human HDAC7 containing phospho-ser155
Host:  rabbit
Appearance:  Liquid
Formulation:  50 µg of peptide-purified IgG in 100 µl of PBS containing 0.05% BSA and 0.05% sodium azide
Applications:  WB
Species Reactivity:  Human HDAC7, Canine HDAC7, Chimpanzee HDAC7, Cow HDAC7, Monkey HDAC7, Mouse HDAC7, Rat HDAC7
Shipping:  Wet ice
Storage:  -20°C
Warning:  For Research Use Only! Not For Use in Humans.
Alternative Name:  Histone Deacetylase 7
Scientific Background:  Histone deacetylase 7 (HDAC7) is a thymus-specific, intracellular transcription factor belonging to the class IIa HDAC family. Reports suggest that dephosphorylation and nuclear localization of HDAC7 is promoted by myosin phosphatase, thus regulating the repression of Nur77 and inhibition of apoptosis in CD4+/CD8+ double-positive thymocytes. HDAC7 plays a specific role in maintaining vascular integrity by repressing the expression of matrix metalloproteinase (MMP) 10. It promotes repression mediated by transcriptional corepressor NCOR2 and is an efficient corepressor of the androgen receptor (AR). It is also responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4).

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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