| Cat.No.: | EAb-0351 |
| Product Name: | MGMT Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | Recombinant human Methylated DNA protein cysteine methyltransferase protein |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Affinity purification |
| Appearance: | Liquid |
| Applications: | WB |
| Recommended Dilutions/Conditions: |
WB: 1:500-1:1000 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Storage Buffer: | PBS with 0.05% Proclin300, 50% glycerol, pH7.3. |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | P16455 |
| Alternative Name: | 6 O methylguanine DNA methyltransferase,6-O-methylguanine-DNA methyltransferase,Agat,AGT,AI267024,EC 2.1.1.63,Methylated DNA protein cysteine methyltransferase,Methylated-DNA--protein-cysteine methyltransferase,Methylguanine DNA methyltransferase,MGC107020,MGMT,MGMT,O 6 methylguanine DNA alkyltransferase,O 6 methylguanine DNA methyltransferase,O-6-methylguanine-DNA methyltransferase,O-6-methylguanine-DNA-alkyltransferase |
| Scientific Background: | Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0142 | Recombinant Human MGMT Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0164 | Lomeguatrib | Inquiry |
| ◆ Antibodies | ||
| EAb-0230 | O6-Methylguanine-DNA methyltransferase Polyclonal Antibody | Inquiry |
| EAb-0351 | MGMT Polyclonal Antibody | Inquiry |
| ◆ Cell Lines | ||
| CL-0394 | Human MGMT Knockout Cell Line 2bp deletion | Inquiry |
| Related Gene / Proteins | |||
| MGMT | |||
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