| Cat.No.: | EAb-0413 |
| Product Name: | ERG Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | Recombinant protein of human ERG |
| Host: | Rabbit |
| Isotype: | IgG |
| Purification: | Affinity purification |
| Appearance: | Liquid |
| Applications: | WB, IHC, ELISA |
| Recommended Dilutions/Conditions: |
WB: 1:500-1:2000; IHC: 1:50-1:200 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse |
| Storage: | -20°C |
| Storage Buffer: | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | P11308 |
| Alternative Name: | Avian erythroblastosis virus E-26 (v-ets) oncogene related,D030036I24Rik,Erg 3,Erg,ERG/EWS fusion gene,included,ERG/FUS fusion gene,included,ERG/TMPSSR2 fusion gene,included,ERG,ERG1,included,ERG2,included,ets related,ETS-related gene,KCNH2,Oncogene ERG,p55,TMPRSS2/ERG fusion,transcriptional regulator ERG (transforming protein ERG),Transcriptional regulator ERG,Transforming protein ERG,v ets avian erythroblastosis virus E26 oncogene,v ets avian erythroblastosis virus E26 oncogene related,v ets erythroblastosis virus E26 oncogene homolog,v ets erythroblastosis virus E26 oncogene like,v ets erythroblastosis virus E26 oncogene like isoform 2,v-ets erythroblastosis virus E26 oncogene,v-ets erythroblastosis virus E26 oncogene homolog (avian),V-ets erythroblastosis virus E26 oncogene like (Avian),isoform CRA_e |
| Scientific Background: | This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0413 | ERG Polyclonal Antibody | Inquiry |
| ◆ Cell Lines | ||
| CL-0421 | Human ERCC6 Knockout Cell Line 26bp deletion | Inquiry |
| CL-0422 | Human ERCC6-PGBD3 Knockout Cell Line | Inquiry |
| CL-0423 | Human ERCC6L Knockout Cell Line 2bp deletion | Inquiry |
| CL-0428 | Human ERCC8 Knockout Cell Line 7bp deletion | Inquiry |
| Related Gene / Proteins | |||
| ERCC6 | ERCC6L | ERCC8 | ERG |
| ERI3 | ERR-α | ||
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