| Cat.No.: | EAb-0504 |
| Product Name: | Lysine (K)-specific Demethylase 5B/KDM5B/JARID1B Polyclonal Antibody |
| Antibody Type: | Polyclonal |
| Immunogen: | The immunogen recognized by this antibody maps to a region between residue 1494 and 1544 of human Jumonji, AT rich interactive domain 1B (NP_006609.3). |
| Host: | Rabbit |
| Isotype: | IgG |
| Antibody Target: | KDM5B |
| Purification: | Immunogen affinity purified |
| Appearance: | Liquid |
| Formulation: | Tris-Citrate/Phosphate (pH 7.0 - 8.0) |
| Applications: | WB, Flow, IHC, IHC-P, IP |
| Recommended Dilutions/Conditions: |
Western Blot 1:2000-1:10000; Flow Cytometry; Immunohistochemistry 1:10-1:500; Immunohistochemistry-Paraffin 1:500-1:2000; Immunoprecipitation 2-5 ug/mg lysate Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human, Mouse |
| Storage: | -20°C |
| Storage Buffer: | 0.09% Sodium Azide |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Alternative Name: | CT31; CT31FLJ10538; EC 1.14.11; EC 1.14.11.-; homolog 1A; Jarid1B; JARID1BFLJ16281; Jumonji, AT rich interactive domain 1B (RBP2-like); jumonji, AT rich interactive domain 1B; KDM5B; Lysine (K)specific Demethylase 5B; Lysine (K)-specific Demethylase 5B; PLU-1; PLU-1FLJ12459; PLU1FLJ23670; PUT1; RBBP2H1; RBBP2H1AFLJ12491; RBP2-H1; Retinoblastoma-binding protein 2 homolog 1 |
| Scientific Background: | JARID1B (Jumonji AT-rich interactive domain 1B) is a member of the JARID 1 family of proteins that catalyze the demethylation of histones on lysine. The Jarid 1 family members include JARID1A, JARID1B, JARID1C and JARID1D. The members of this family possess a Jumonji C (JmjC) and Jumonji N (JmjN) domain as well as one ARID (AT-rich interactive domain) and three PHD-type zinc fingers. As histone demethylases, JARID 1 proteins function as transcriptional repressors. JARID1B expression is largely restricted to testis and may play a critical role in tumorigenesis as it has been found to be upregulated in prostate and breast cancer. Alternative names for JARID1B include retinoblastoma-binding protein 2 homolog 1, RBP2-H1, cancer/testis antigen 31, CT31, PLU-1, PUT1, and KDM5B. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0002 | AT9283 | Inquiry |
| ◆ Cell Lines | ||
| CL-0015 | Human KDM5B Knockout Cell Line 14bp deletion | Inquiry |
| CL-0017 | Human JARID2 Knockout Cell Line 11bp deletion | Inquiry |
| ◆ Antibodies | ||
| EAb-0071 | KDM1B Polyclonal Antibody | Inquiry |
| EAb-0079 | JARID2 Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| JADE1 | JAK | JAK1 | JAK2 |
| JAK3 | JAKMIP1 | JARID | JARID1 |
| JARID1A | JARID1B | JARID1C | JARID2 |
| KDM1 | KDM1A | KDM1B | KDM2 |
| KDM2A | KDM2B | KDM3A | KDM3B More > |
| KDM4 | KDM4A | KDM4B | KDM4C |
| KDM4D | KDM4E | KDM5 | KDM5A |
| KDM5B | KDM5C | KDM5D | KDM6A |
| KDM6B | KDM6C | KDM7 | KDM7A |
| KDM7B | KDM8 | ||
USA
Enter your email here to subscribe.
Follow us on
Easy access to products and services you need from our library via powerful searching tools
