| Cat.No.: | EAb-0524 |
| Product Name: | Lysine (K)-specific Demethylase 4C/KDM4C/JMJD2C Monoclonal Antibody (OTI5B9) |
| Antibody Type: | Monoclonal |
| Clone Designation: | OTI5B9 |
| Immunogen: | Full-length protein expressed in 293T cell transfected with human KDM4C expression vector |
| Host: | Mouse |
| Isotype: | IgG1 |
| Antibody Target: | KDM4C |
| Specificity: | This antibody is specific for Homo sapiens lysine (K)-specific demethylase 4C (KDM4C), transcript variant 1. |
| Purification: | Immunogen affinity purified |
| Appearance: | Liquid |
| Formulation: | PBS (pH 7.3), 1.0% BSA and 50% Glycerol |
| Applications: | WB, ICC/IF, IHC, IHC-P |
| Recommended Dilutions/Conditions: |
Western Blot 1:2000; Immunocytochemistry/Immunofluorescence 1:100; Immunohistochemistry 1:50; Immunohistochemistry-Paraffin 1:50 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Species Reactivity: | Human |
| Storage: | -20°C |
| Storage Buffer: | 0.02% Sodium Azide |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Alternative Name: | EC 1.14.11; EC 1.14.11.-; GASC-1 protein; GASC1; GASC1JmjC domain-containing histone demethylation protein 3C; Gene amplified in squamous cell carcinoma 1 protein; JHDM3C; JMJD2C; JMJD2CbA146B14.1; jumonji domain containing 2C; Jumonji domain-containing protein 2C; KDM4C; KIAA0780FLJ25949; Lysine (K)specific Demethylase 4C; Lysine (K)-specific Demethylase 4C; lysine-specific demethylase 4C |
| Scientific Background: | This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. Alternative splicing results in multiple transcript variants. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0015 | Human KDM5B Knockout Cell Line 14bp deletion | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Antibodies | ||
| EAb-0071 | KDM1B Polyclonal Antibody | Inquiry |
| EAb-0072 | JMJD6 Polyclonal Antibody | Inquiry |
| EAb-0074 | JMJD2c Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| JMJD | JMJD1A | JMJD1B | JMJD1C |
| JMJD2 | JMJD2A | JMJD2B | JMJD2C |
| JMJD2D | JMJD2E | JMJD2F | JMJD3 |
| JMJD4 | JMJD5 | JMJD6 | KDM1 |
| KDM1A | KDM1B | KDM2 | KDM2A More > |
| KDM2B | KDM3A | KDM3B | KDM4 |
| KDM4A | KDM4B | KDM4C | KDM4D |
| KDM4E | KDM5 | KDM5A | KDM5B |
| KDM5C | KDM5D | KDM6A | KDM6B |
| KDM6C | KDM7 | KDM7A | KDM7B |
| KDM8 | |||
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