| Cat.No.: | EAb-0565 |
| Product Name: | HDAC3 Monoclonal Antibody |
| Product Overview: | Anti-HDAC3 (MOUSE) Monoclonal Antibody |
| Antibody Type: | Monoclonal |
| Immunogen: | Produced in mice by repeated immunization with a synthetic peptide containing a sequence from the C-terminal region of the human HDAC3 protein. |
| Host: | Mouse |
| Isotype: | IgG1 |
| Purification: | Purified by Protein A chromatography. |
| Appearance: | Liquid |
| Formulation: | 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2 |
| Applications: | Chromatin Immunoprecipitation and Immunofluorescence |
| Recommended Dilutions/Conditions: |
ChIP: 2 μg/ChIP; IF Microscopy: 1:500 Recommended dilutions/conditions may not be available for all applications. Specific conditions for reactivity should be optimized by the end user. |
| Cross Reactivity: | Human |
| Shipping: | Dry Ice |
| Storage: | -20°C |
| Storage Buffer: | 0.05% (w/v) Sodium Azide and 0.05% ProClin 300 |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Accession: | UniProtKB - O15379; GeneID - 8841; NCBI - NP_003874.2 |
| Alternative Name: | HD3, RPD3-2, SMAP45 |
| Scientific Background: | HDAC3 catalyses the deacetylation of lysine residues in the N-terminal part of the core histones (H2A, H2B, H3 and H4). Acetylation and deacetylation of these highly conserved lysine residues is important for the control of gene expression and HDAC activity is associated with gene repression. Histone deacetylation is established by the formation of large multiprotein complexes. HDAC3 may bind to the zinc-finger transcription factor YY1, thereby regulating transcription. It is also able to modulate cell growth and apoptosis through the interaction with p53 and is thought to be essential for the repression of the POU1F1 transcription factor. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
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